ArticleProceedings of the National Academy of Sciences of the United States of America2014
Evolution of a plant-specific copper chaperone family for chloroplast copper homeostasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
- Barriers and carriers for transition metal homeostasis in plants.Plant communications · 2025Review
- The petunia heavy metal P-type ATPase PhHMA5II1 interacts with copper chaperons and regulate Cu detoxification.Plant cell reports · 2025Article
- Copper connections: coordinating transport, sensing and systemic signalling in plants.Quantitative plant biology · 2025Review
- Molecular Mechanisms of Plant Responses to Copper: From Deficiency to Excess.International journal of molecular sciences · 2024Review
- Ascorbate Peroxidase 2 (APX2) of Chlamydomonas Binds Copper and Modulates the Copper Insertion into Plastocyanin.Antioxidants (Basel, Switzerland) · 2023Article
- Physiological and Molecular Mechanisms of Plant Responses to Copper Stress.International journal of molecular sciences · 2022Review
- Energy status-promoted growth and development of Arabidopsis require copper deficiency response transcriptional regulator SPL7.The Plant cell · 2022Article
- The mitochondrial CuFrontiers in molecular biosciences · 2022Article
- Adaptive Responses ofInternational journal of molecular sciences · 2021Article
- YSL3-mediated copper distribution is required for fertility, seed size and protein accumulation in Brachypodium.Plant physiology · 2021Article
- Article
- Cyanobacteria provide a new paradigm in the regulation of cofactor dependence.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- From economy to luxury: Copper homeostasis in Chlamydomonas and other algae.Biochimica et biophysica acta. Molecular cell research · 2020Review
- Article
- Regulating cellular trace metal economy in algae.Current opinion in plant biology · 2017Review
- Specific reverse transcriptase slippage at the HIV ribosomal frameshift sequence: potential implications for modulation of GagPol synthesis.Nucleic acids research · 2017Article
- Copper homeostasis networks in the bacteriumThe Journal of biological chemistry · 2017Article
- Membrane Anchoring and Ion-Entry Dynamics in P-type ATPase Copper Transport.Biophysical journal · 2016Article
- Identification of Two Conserved Residues Involved in Copper Release from Chloroplast PIB-1-ATPases.The Journal of biological chemistry · 2016Article
- Bacterial Cu(+)-ATPases: models for molecular structure-function studies.Metallomics : integrated biometal science · 2016Review
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Metallochaperones traffic copper (Cu(+)) from its point of entry at the plasma membrane to its destination. In plants, one destination is the chloroplast, which houses plastocyanin, a Cu-dependent electron transfer protein involved in photosynthesis. We present a previously unidentified Cu(+) chaperone that evolved early in the plant lineage by an alternative-splicing event of the pre-mRNA encoding the chloroplast P-type ATPase in Arabidopsis 1 (PAA1). In several land plants, recent duplication events created a separate chaperone-encoding gene coincident with loss of alternative splicing. The plant-specific Cu(+) chaperone delivers Cu(+) with specificity for PAA1, which is flipped in the envelope relative to prototypical bacterial ATPases, compatible with a role in Cu(+) import into the stroma and consistent with the canonical catalytic mechanism of these enzymes. The ubiquity of the chaperone suggests conservation of this Cu(+)-delivery mechanism and provides a unique snapshot into the evolution of a Cu(+) distribution pathway. We also provide evidence for an interaction between PAA2, the Cu(+)-ATPase in thylakoids, and the Cu(+)-chaperone for Cu/Zn superoxide dismutase (CCS), uncovering a Cu(+) network that has evolved to fine-tune Cu(+) distribution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.