ArticleDevelopment (Cambridge, England)2014
Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 69 citations in OpenAlex.
- Progress in understanding the vertebrate segmentation clock.Nature reviews. Genetics · 2025Review
- DeltaC and DeltaD ligands play different roles in the segmentation clock dynamics.Nature communications · 2025Article
- Cellular and molecular control of vertebrate somitogenesis.Nature reviews. Molecular cell biology · 2024Review
- The Clock and Wavefront Self-Organizing model recreates the dynamics of mouse somitogenesis in vivo and in vitro.Development (Cambridge, England) · 2024Article
- Oscillatory control of embryonic development.Development (Cambridge, England) · 2024Review
- Lfng and Dll3 cooperate to modulate protein interactions in cis and coordinate oscillatory Notch pathway activation in the segmentation clock.Developmental biology · 2022Article
- The vertebrate Embryo Clock: Common players dancing to a different beat.Frontiers in cell and developmental biology · 2022Review
- Dll1 Can Function as a Ligand of Notch1 and Notch2 in the Thymic Epithelium.Frontiers in immunology · 2022Article
- Activity of the mouse Notch ligand DLL1 is sensitive to C-terminal tagging in vivo.BMC research notes · 2021Article
- Light Control of Gene Expression Dynamics.Advances in experimental medicine and biology · 2021Review
- Article
- Xylosyl Extension ofCells · 2020Article
- Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models.Frontiers in physiology · 2020Review
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- Article
- Myc activity is required for maintenance of the neuromesodermal progenitor signalling network and for segmentation clock gene oscillations in mouse.Development (Cambridge, England) · 2018Article
- ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock.Development (Cambridge, England) · 2018Article
- VRTN is Required for the Development of Thoracic Vertebrae in Mammals.International journal of biological sciences · 2018Article
- Article
- Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information.Genes & development · 2017Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
During somitogenesis, epithelial somites form from the pre-somitic mesoderm (PSM) in a periodic manner. This periodicity is regulated by a molecular oscillator, known as the 'segmentation clock', that is characterised by an oscillatory pattern of gene expression that sweeps the PSM in a caudal-rostral direction. Key components of the segmentation clock are intracellular components of the Notch, Wnt and FGF pathways, and it is widely accepted that intracellular negative-feedback loops regulate oscillatory gene expression. However, an open question in the field is how intracellular oscillations are coordinated, in the form of spatiotemporal waves of expression, across the PSM. In this study, we provide a potential mechanism for this process. We show at the mRNA level that the Notch1 receptor and Delta-like 1 (Dll1) ligand vary dynamically across the PSM of both chick and mouse. Remarkably, we also demonstrate similar dynamics at the protein level; hence, the pathway components that mediate intercellular coupling themselves exhibit oscillatory dynamics. Moreover, we quantify the dynamic expression patterns of Dll1 and Notch1, and show they are highly correlated with the expression patterns of two known clock components [Lfng mRNA and the activated form of the Notch receptor (cleaved Notch intracellular domain, NICD)]. Lastly, we show that Notch1 is a target of Notch signalling, whereas Dll1 is Wnt regulated. Regulation of Dll1 and Notch1 expression thus links the activity of Wnt and Notch, the two main signalling pathways driving the clock.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.