ArticleDevelopment (Cambridge, England)2014
Evolutionary changes in TGFα distribution underlie morphological diversity in eggshells from Drosophila species.
Article in Development (Cambridge, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A computational framework to study EGFR signaling distribution in egg chambers during dynamic interactions between soma and germline.PLoS computational biology · 2025Article
- Diversity ofFrontiers in cell and developmental biology · 2025Article
- Finishing the egg.Genetics · 2024Article
- Nebulous without white: annotated long-read genome assembly and CRISPR/Cas9 genome engineering in Drosophila nebulosa.G3 (Bethesda, Md.) · 2022Article
- Quantitative analyses of EGFR localization and trafficking dynamics in the follicular epithelium.Development (Cambridge, England) · 2020Article
- Quantifying the extent of morphological homoplasy: A phylogenetic analysis of 490 characters inEvolution letters · 2019Article
- Two Drosophilids exhibit distinct EGF pathway patterns in oogenesis.Development genes and evolution · 2018Article
- Gene regulation duringProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Epithelial Patterning, Morphogenesis, and Evolution: Drosophila Eggshell as a Model.Developmental cell · 2017Review
- Diversity of epithelial morphogenesis during eggshell formation in drosophilids.Development (Cambridge, England) · 2015Article
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Authors and funding
2 authors.
Funding
Abstract
Drosophila eggshells display remarkable morphological diversity among species; however, the molecular origin of this structural diversification is mostly unknown. Here, we analyzed the dorsal ridge (DR), a lumen-like structure along the dorsal side of eggshells, from numerous Drosophila species. This structure varies in length and width across species, and is absent from D. melanogaster eggshells. We associated DR formation with distinct spatiotemporal changes in epidermal growth factor receptor (EGFR) activation, which acts as a key receptor in eggshell patterning. We show that changes in the distribution of the TGFα-like ligand Gurken (GRK), a crucial ligand for axis formation, underlies EGFR activation and DR formation in D. willistoni. Furthermore, we demonstrate that GRK from D. willistoni rescues a grk-null D. melanogaster fly and, remarkably, it is also sufficient to generate a DR-like structure on its eggshell.
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