ArticleMolecular biology and evolution2015
The Y-chromosome tree bursts into leaf: 13,000 high-confidence SNPs covering the majority of known clades.
Article in Molecular biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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84 citing papers in PubMed.
- A high-resolution Y-chromosomal panel for forensic paternal lineage tracing and anthropological insight: unraveling the genetic structure of the Dongxiang ethnic minority.International journal of legal medicine · 2026Article
- Rare uniparental lineages reveal external ancestries in the gene pool of the Italian linguistic enclave of Grecìa Salentina.Scientific reports · 2025Article
- Introducing the Y-chromosomal Ancestral-like Reference Sequence-Improving the Capture of Human Evolutionary Information.Molecular biology and evolution · 2025Article
- Y-mer: a k-mer based method for determining human Y chromosome haplogroups from ultra-low sequencing depth data.Genome biology · 2025Article
- UYSD: a novel data repository accessible via public website for worldwide population frequencies of Y-SNP haplogroups.European journal of human genetics : EJHG · 2025Article
- Urbanization and genetic homogenization in the medieval Low Countries revealed through a ten-century paleogenomic study of the city of Sint-Truiden.Genome biology · 2025Article
- Sex-Biased Admixture Followed by Isolation and Adaptive Evolution Shaped the Genomic and Blood Pressure Diversity of the LopNur People.Molecular biology and evolution · 2025Article
- Resolving the source of branch length variation in the Y chromosome phylogeny.Genome biology · 2025Article
- Characterization of Y chromosome diversity in newfoundland and labrador: evidence for a structured founding population.European journal of human genetics : EJHG · 2025Article
- Low Genetic Impact of the Roman Occupation of Britain in Rural Communities.Molecular biology and evolution · 2024Article
- Human Y chromosome haplogroup L1-M22 traces Neolithic expansion in West Asia and supports the Elamite and Dravidian connection.iScience · 2024Article
- Genetic history of Cambridgeshire before and after the Black Death.Science advances · 2024Article
- Application of Targeted Y-Chromosomal Capture Enrichment to Increase the Resolution of Native American Haplogroup Q.Human mutation · 2024Article
- Developmental validation of the AGCU YNFS Y Kit: A new 6-dye multiplex system with 44 Y-STRs and 5 Y-InDels for forensic application.PloS one · 2024Article
- Genetic evidence points to distinct paternal settlers of the Faroe Islands and Iceland.Frontiers in genetics · 2024Article
- Forensic biogeographical ancestry inference: recent insights and current trends.Genes & genomics · 2023Review
- Article
- Multiple founding paternal lineages inferred from the newly-developed 639-plex Y-SNP panel suggested the complex admixture and migration history of Chinese people.Human genomics · 2023Article
- Episodes of Diversification and Isolation in Island Southeast Asian and Near Oceanian Male Lineages.Molecular biology and evolution · 2022Article
- The Genetic Origin of Daunians and the Pan-Mediterranean Southern Italian Iron Age Context.Molecular biology and evolution · 2022Article
24 more citing papers are in PubMed but not listed here.
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29 authors.
Funding
Abstract
Many studies of human populations have used the male-specific region of the Y chromosome (MSY) as a marker, but MSY sequence variants have traditionally been subject to ascertainment bias. Also, dating of haplogroups has relied on Y-specific short tandem repeats (STRs), involving problems of mutation rate choice, and possible long-term mutation saturation. Next-generation sequencing can ascertain single nucleotide polymorphisms (SNPs) in an unbiased way, leading to phylogenies in which branch-lengths are proportional to time, and allowing the times-to-most-recent-common-ancestor (TMRCAs) of nodes to be estimated directly. Here we describe the sequencing of 3.7 Mb of MSY in each of 448 human males at a mean coverage of 51×, yielding 13,261 high-confidence SNPs, 65.9% of which are previously unreported. The resulting phylogeny covers the majority of the known clades, provides date estimates of nodes, and constitutes a robust evolutionary framework for analyzing the history of other classes of mutation. Different clades within the tree show subtle but significant differences in branch lengths to the root. We also apply a set of 23 Y-STRs to the same samples, allowing SNP- and STR-based diversity and TMRCA estimates to be systematically compared. Ongoing purifying selection is suggested by our analysis of the phylogenetic distribution of nonsynonymous variants in 15 MSY single-copy genes.
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