Evidence map›Paper›PMID 25468793›Full record

ArticleTrends in microbiology2014

The end of Nef's tether.

Ruth Serra-Moreno

Abstract readComment
In one paragraph

Article in Trends in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Ruth Serra-MorenoDepartment of Biological Sciences, College of Arts and Sciences, Texas Tech University, 8(th) and Canton Avenue, Lubbock, TX 79409-3131, USA. Electronic address: ruth.serra-moreno@ttu.edu.

Funding

Characterization of the antiviral activity of BCA2R21AI106400 · NIAID · TEXAS TECH UNIVERSITY · PI SERRA MORENO, RUTH · 2014 to 2015
$398k
NIAID NIH HHS R21 AI106400PHS HHS NIH/NIAID R21AI106400
6 · The paper itself

Abstract

Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa.

Indexed as

Antigens, CDHIV-1Humansnef Gene Products, Human Immunodeficiency VirusAntigens, CDnef Gene Products, Human Immunodeficiency VirusHIVNefrestrictiontetherin

Identifiers

PMID25468793
PMCPMC4258156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.