ArticleDevelopmental cell2014
Calcium-dependent neuroepithelial contractions expel damaged cells from the developing brain.
Article in Developmental cell, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Higher-order thalamocortical circuits are specified by embryonic cortical progenitor types in the mouse brain.Cell reports · 2024Article
- Embryos assist morphogenesis of others through calcium and ATP signaling mechanisms in collective teratogen resistance.Nature communications · 2024Article
- Epithelial wound healing in Clytia hemisphaerica provides insights into extracellular ATP signaling mechanisms and P2XR evolution.Scientific reports · 2023Article
- Macrophages trigger cardiomyocyte proliferation by increasing epicardial vegfaa expression during larval zebrafish heart regeneration.Developmental cell · 2022Article
- A simple mechanochemical model for calcium signalling in embryonic epithelial cells.Journal of mathematical biology · 2019Article
- Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injuryDevelopment (Cambridge, England) · 2019Article
- Calcium Signaling in Vertebrate Development and Its Role in Disease.International journal of molecular sciences · 2018Review
- Intestinal crypts recover rapidly from focal damage with coordinated motion of stem cells that is impaired by aging.Scientific reports · 2018Article
- Targeted two-photon chemical apoptotic ablation of defined cell types in vivo.Nature communications · 2017Article
- Calcium spikes, waves and oscillations in a large, patterned epithelial tissue.Scientific reports · 2017Article
- Mapping neurogenesis onset in the optic tectum of Xenopus laevis.Developmental neurobiology · 2016Article
- The cellular and molecular mechanisms of tissue repair and regeneration as revealed by studies inRegeneration (Oxford, England) · 2016Article
- Cell biology: Death drags down the neighbourhood.Nature · 2015Article
- DAMPs from Cell Death to New Life.Frontiers in immunology · 2015Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Both developing and adult organisms need efficient strategies for wound repair. In adult mammals, wounding triggers an inflammatory response that can exacerbate tissue injury and lead to scarring. In contrast, embryonic wounds heal quickly and with minimal inflammation, but how this is achieved remains incompletely understood. Using in vivo imaging in the developing brain of Xenopus laevis, we show that ATP release from damaged cells and subsequent activation of purinergic receptors induce long-range calcium waves in neural progenitor cells. Cytoskeletal reorganization and activation of the actomyosin contractile machinery in a Rho kinase-dependent manner then lead to rapid and pronounced apical-basal contractions of the neuroepithelium. These contractions drive the expulsion of damaged cells into the brain ventricle within seconds. Successful cell expulsion prevents the death of nearby cells and an exacerbation of the injury. Cell expulsion through neuroepithelial contraction represents a mechanism for rapid wound healing in the developing brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.