ArticleCell and tissue research2015
Expression of pluripotency factors in echinoderm regeneration.
Article in Cell and tissue research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 62 citations in OpenAlex.
- Echinoderm Radial Glia-Like Cells Express Vertebrate Glial Markers.The Journal of comparative neurology · 2025Article
- Article
- Single-cell RNA sequencing of the holothurian regenerating intestine reveals the pluripotency of the coelomic epithelium.bioRxiv : the preprint server for biology · 2024Article
- A wound-induced differentiation trajectory for neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- TMT-Based Quantitative Proteomic Analysis Reveals the Key Role of Cell Proliferation and Apoptosis in Intestine Regeneration ofInternational journal of molecular sciences · 2024Article
- Review
- Manipulating Myc for reparative regeneration.Frontiers in cell and developmental biology · 2024Review
- Transcriptomic analysis reveals the early body wall regeneration mechanism of the sea cucumber Holothuria leucospilota after artificially induced transverse fission.BMC genomics · 2023Article
- Ethical Considerations for Echinoderms: New Initiatives in Welfare.Animals : an open access journal from MDPI · 2023Review
- Mesentery AjFGF4-AjFGFR2-ERK pathway modulates intestinal regeneration via targeting cell cycle in echinoderms.Cell proliferation · 2023Article
- Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration.Frontiers in neural circuits · 2023Review
- The salamander blastema within the broader context of metazoan regeneration.Frontiers in cell and developmental biology · 2023Review
- A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians.Biology · 2022Review
- The functional diversity of the POUV-class proteins across vertebrates.Open biology · 2022Review
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Regeneration of the larval sea star nervous system by wounding induced respecification to the Sox2 lineage.eLife · 2022Article
- Radial glia and radial glia-like cells: Their role in neurogenesis and regeneration.Frontiers in neuroscience · 2022Review
- Ancestral Stem Cell Reprogramming Genes Active in Hemichordate Regeneration.Frontiers in ecology and evolution · 2022Article
- Wnt/β-catenin signaling pathway regulates cell proliferation but not muscle dedifferentiation nor apoptosis during sea cucumber intestinal regeneration.Developmental biology · 2021Article
- Expression ofGenes · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cell dedifferentiation is an integral component of post-traumatic regeneration in echinoderms. As dedifferentiated cells become multipotent, we asked if this spontaneous broadening of developmental potential is associated with the action of the same pluripotency factors (known as Yamanaka factors) that were used to induce pluripotency in specialized mammalian cells. In this study, we investigate the expression of orthologs of the four Yamanaka factors in regeneration of two different organs, the radial nerve cord and the digestive tube, in the sea cucumber Holothuria glaberrima. All four pluripotency factors are expressed in uninjured animals, although their expression domains do not always overlap. In regeneration, the expression levels of the four genes were not regulated in a coordinated way, but instead showed different dynamics for individual genes and also were different between the radial nerve and the gut. SoxB1, the ortholog of the mammalian Sox2, was drastically downregulated in the regenerating intestine, suggesting that this factor is not required for dedifferentiation/regeneration in this organ. On the other hand, during the early post-injury stage, Myc, the sea cucumber ortholog of c-Myc, was significantly upregulated in both the intestine and the radial nerve cord and is therefore hypothesized to play a central role in dedifferentiation/regeneration of various tissue types.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.