ArticleBiophysical journal2014
Mechanics of individual keratin bundles in living cells.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 48 citations in OpenAlex.
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- Response of cells and tissues to shear stress.Journal of cell science · 2023Review
- Review
- From Strain Stiffening to Softening-Rheological Characterization of Keratins 8 and 18 Networks Crosslinked via Electron Irradiation.Polymers · 2022Article
- Negative tension controls stability and structure of intermediate filament networks.Scientific reports · 2022Article
- Finite Element Simulations of Mechanical Behaviour of Endothelial Cells.BioMed research international · 2021Article
- Propagating acoustic waves on a culture substrate regulate the directional collective cell migration.Microsystems & nanoengineering · 2021Article
- Model for Bundling of Keratin Intermediate Filaments.Biophysical journal · 2020Article
- Physics of animal health: on the mechano-biology of hoof growth and form.Journal of the Royal Society, Interface · 2019Article
- Modelling Cell Origami via a Tensegrity Model of the Cytoskeleton in Adherent Cells.Applied bionics and biomechanics · 2019Article
- The Osteoprotective Effects Of Kaempferol: The Evidence From In Vivo And In Vitro Studies.Drug design, development and therapy · 2019Review
- Article
- The desmoplakin-intermediate filament linkage regulates cell mechanics.Molecular biology of the cell · 2017Article
- A rim-and-spoke hypothesis to explain the biomechanical roles for cytoplasmic intermediate filament networks.Journal of cell science · 2017Review
- Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics.Cold Spring Harbor perspectives in biology · 2017Review
- Modest Static Pressure Suppresses Columnar Epithelial Cell Growth in Association with Cell Shape and Cytoskeletal Modifications.Frontiers in physiology · 2017Article
- Intermediate Filaments at the Junction of Mechanotransduction, Migration, and Development.Frontiers in cell and developmental biology · 2017Review
- Semiflexible Biopolymers in Bundled Arrangements.Polymers · 2016Review
- Intermediate filament mechanics in vitro and in the cell: from coiled coils to filaments, fibers and networks.Current opinion in cell biology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Along with microtubules and microfilaments, intermediate filaments are a major component of the eukaryotic cytoskeleton and play a key role in cell mechanics. In cells, keratin intermediate filaments form networks of bundles that are sparser in structure and have lower connectivity than, for example, actin networks. Because of this, bending and buckling play an important role in these networks. Buckling events, which occur due to compressive intracellular forces and cross-talk between the keratin network and other cytoskeletal components, are measured here in situ. By applying a mechanical model for the bundled filaments, we can access the mechanical properties of both the keratin bundles themselves and the surrounding cytosol. Bundling is characterized by a coupling parameter that describes the strength of the linkage between the individual filaments within a bundle. Our findings suggest that coupling between the filaments is mostly complete, although it becomes weaker for thicker bundles, with some relative movement allowed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.