ArticleBiophysical journal2014
Self-organizing actomyosin patterns on the cell cortex at epithelial cell-cell junctions.
Article in Biophysical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Unveiling the physics underlying symmetry breaking of the actin cytoskeleton: An artificial cell-based approach.Biophysics and physicobiology · 2023Article
- Role of actin filaments and cis binding in cadherin clustering and patterning.PLoS computational biology · 2022Article
- Multicellular contractility contributes to the emergence of mesothelioma nodules.Scientific reports · 2020Article
- Actomyosin Contraction Induces In-Bulk Motility of Cells and Droplets.Biophysical journal · 2020Article
- Editorial: Forces in Biology - Cell and Developmental Mechanobiology and Its Implications in Disease.Frontiers in cell and developmental biology · 2020Article
- Spatio-Temporal Regulation of RhoGTPases Signaling by Myosin II.Frontiers in cell and developmental biology · 2019Review
- Hypothesis: Caco-2 cell rotational 3D mechanogenomic turing patterns have clinical implications to colon crypts.Journal of cellular and molecular medicine · 2018Article
- Emergent mechanics of actomyosin drive punctuated contractions and shape network morphology in the cell cortex.PLoS computational biology · 2018Article
- Bistable front dynamics in a contractile medium: Travelling wave fronts and cortical advection define stable zones of RhoA signaling at epithelial adherens junctions.PLoS computational biology · 2017Article
- Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.Nature cell biology · 2015Article
- Open source software for quantification of cell migration, protrusions, and fluorescence intensities.The Journal of cell biology · 2015Article
- Function of metabolic and organelle networks in crowded and organized media.Frontiers in physiology · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The behavior of actomyosin critically determines morphologically distinct patterns of contractility found at the interface between adherent cells. One such pattern is found at the apical region (zonula adherens) of cell-cell junctions in epithelia, where clusters of the adhesion molecule E-cadherin concentrate in a static pattern. Meanwhile, E-cadherin clusters throughout lateral cell-cell contacts display dynamic movements in the plane of the junctions. To gain insight into the principles that determine the nature and organization of these dynamic structures, we analyze this behavior by modeling the 2D actomyosin cell cortex as an active fluid medium. The numerical simulations show that the stability of the actin filaments influences the spatial structure and dynamics of the system. We find that in addition to static Turing-type patterns, persistent dynamic behavior occurs in a wide range of parameters. In the 2D model, mechanical stress-dependent actin breakdown is shown to produce a continuously changing network of actin bridges, whereas with a constant breakdown rate, more isolated clusters of actomyosin tend to form. The model qualitatively reproduces the dynamic and stable patterns experimentally observed at the junctions between epithelial cells.
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