ArticleJournal of biomechanics2015
Resurfacing damaged articular cartilage to restore compressive properties.
Article in Journal of biomechanics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Injection route affects intra-articular hyaluronic acid distribution and clinical outcome in viscosupplementation treatment for knee osteoarthritis: a combined cadaver study and randomized clinical trial.Drug delivery and translational research · 2021Trial
- Interstitial Fluid Load Support in Human Articular Cartilage: Effects of Degeneration, Loading, and Material Properties via Combined Experimental Testing and Computational Modeling.Annals of biomedical engineering · 2026Article
- Exploring mechanisms governing cartilage interstitial fluid load support in lubrication through experimental and computational analysis.Scientific reports · 2026Article
- Mechanical Wear of Degraded Articular Cartilage.Annals of biomedical engineering · 2025Article
- Exogenous Collagen Crosslinking is Highly Detrimental to Articular Cartilage Lubrication.Journal of biomechanical engineering · 2024Article
- Improved Cartilage Protection with Low Molecular Weight Hyaluronic Acid Hydrogel.Bioengineering (Basel, Switzerland) · 2023Article
- In Vitro Analysis of Human Cartilage Infiltrated by Hydrogels and Hydrogel-Encapsulated Chondrocytes.Bioengineering (Basel, Switzerland) · 2023Article
- Correlation analysis of cartilage wear with biochemical composition, viscoelastic properties and friction.Journal of the mechanical behavior of biomedical materials · 2023Article
- Effect of Articular Surface Compression on Cartilage Extracellular Matrix Deformation.Journal of biomechanical engineering · 2022Article
- Stabilization of Damaged Articular Cartilage with Hydrogel-Mediated Reinforcement and Sealing.Advanced healthcare materials · 2021Article
- Experimental Study on Creep Characteristics of Microdefect Articular Cartilages in the Damaged Early Stage.Journal of healthcare engineering · 2019Article
- Article
- Active agents, biomaterials, and technologies to improve biolubrication and strengthen soft tissues.Biomaterials · 2018Review
- Photocrosslinked tyramine-substituted hyaluronate hydrogels with tunable mechanical properties improve immediate tissue-hydrogel interfacial strength in articular cartilage.Journal of biomaterials science. Polymer edition · 2017Article
- Improved Osteoblast and Chondrocyte Adhesion and Viability by Surface-Modified Ti6Al4V Alloy with Anodized TiO₂ Nanotubes Using a Super-Oxidative Solution.Materials (Basel, Switzerland) · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Surface damage to articular cartilage is recognized as the initial underlying process causing the loss of mechanical function in early-stage osteoarthritis. In this study, we developed structure-modifying treatments to potentially prevent, stabilize or reverse the loss in mechanical function. Various polymers (chondroitin sulfate, carboxymethylcellulose, sodium hyaluronate) and photoinitiators (riboflavin, irgacure 2959) were applied to the surface of collagenase-degraded cartilage and crosslinked in situ using UV light irradiation. While matrix permeability and deformation significantly increased following collagenase-induced degradation of the superficial zone, resurfacing using tyramine-substituted sodium hyaluronate and riboflavin decreased both values to a level comparable to that of intact cartilage. Repetitive loading of resurfaced cartilage showed minimal variation in the mechanical response over a 7 day period. Cartilage resurfaced using a low concentration of riboflavin had viable cells in all zones while a higher concentration resulted in a thin layer of cell death in the uppermost superficial zone. Our approach to repair surface damage initiates a new therapeutic advance in the treatment of injured articular cartilage with potential benefits that include enhanced mechanical properties, reduced susceptibility to enzymatic degradation and reduced adhesion of macrophages.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.