ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2015
Enhanced dorsal premotor-motor inhibition in cervical dystonia.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Neural Substrates for Head Movements in Humans: A Functional Magnetic Resonance Imaging Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Trial
- Repetitive transcranial magnetic stimulation in cervical dystonia: effect of site and repetition in a randomized pilot trial.PloS one · 2015Trial
- Versatility of Transcranial Magnetic Stimulation: A Review of Diagnostic and Therapeutic Applications.Brain sciences · 2026Review
- Pallido-putaminal connectivity predicts outcomes of deep brain stimulation for cervical dystonia.Brain : a journal of neurology · 2021Article
- Abnormal Network Homogeneity in the Right Superior Medial Frontal Gyrus in Cervical Dystonia.Frontiers in neurology · 2021Article
- Defining research priorities in dystonia.Neurology · 2020Review
- Network localization of cervical dystonia based on causal brain lesions.Brain : a journal of neurology · 2019Article
- Increased Finger-Tapping Related Cerebellar Activation in Cervical Dystonia, Enhanced by Transcranial Stimulation: An Indicator of Compensation?Frontiers in neurology · 2019Article
- Isolated Focal Dystonia as a Disorder of Large-Scale Functional Networks.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Multiple Neural Networks Malfunction in Primary Blepharospasm: An Independent Components Analysis.Frontiers in human neuroscience · 2017Article
- A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia.Frontiers in neurology · 2016Article
- Contribution of TMS and rTMS in the Understanding of the Pathophysiology and in the Treatment of Dystonia.Frontiers in neural circuits · 2016Review
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Abstract
objectiveThis study aims to understand whether the enhanced dPMI, seen in writer's cramp patients previously, extends to other populations of focal dystonia patients (e.g. cervical dystonia) as an endophenotypic marker.
methodsWe studied 9 healthy subjects and 9 patients with CD. dPMI was tested by applying conditioning transcranial magnetic stimulation to the left dorsal premotor cortex and then a test pulse to the ipsilateral motor cortex at an interval of 6ms. We also looked at the duration of the cortical silent period (CSP)-a measure of cortical excitability.
resultsCD patients had enhanced dPMI at rest (mean 57.0%, SD 16.2) in contrast to healthy volunteers (mean 124.1%, SD 35.7) (p<0.001). CSP latencies (in ms) in CD patients (mean 108.0, SD 33.1) were significantly shorter than in healthy volunteers (mean 159.1, SD 55.2) (p<0.05).
conclusionsCD patients showed enhanced dPMI in a hand muscle-distant from their affected body part-similar to writer's cramp patients. This enhanced inhibition was independent of disease severity and neck posture. This suggests that enhanced dPMI may be an endophenotypic marker of dystonia. SIGNIFICANCE: The abnormal dorsal premotor-motor connection in cervical dystonia is a potential novel and important avenue for therapeutic targeting.
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