SynthesisSchizophrenia research2014
Mirror neuron dysfunction in schizophrenia and its functional implications: a systematic review.
Synthesis in Schizophrenia research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The mirror mechanism in schizophrenia: A systematic review and qualitative meta-analysis.Frontiers in psychiatry · 2022Pooled it
- Transdiagnostic associations between subjective gesture behaviour and objective performance in schizophrenia and depression.Translational psychiatry · 2026Article
- The Concept of Autism in Autism Spectrum Disorder and Schizophrenia Spectrum Disorder: Historical Divergence and Phenomenological Rapprochement.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2026Review
- Frontal-striatal-thalamic circuit dysfunction and inferential processing between internal representations and external events across the psychosis spectrum.Frontiers in psychiatry · 2026Review
- GABAergic and glutamatergic mechanisms of cortical excitability shape motor resonance during action observation as measured by transcranial magnetic stimulation.Frontiers in human neuroscience · 2026Article
- Attachment in Schizophrenia: Its Associations with Theory of Mind, Childhood Trauma and Psychosocial Functioning.Turk psikiyatri dergisi = Turkish journal of psychiatry · 2026Article
- Relational Impact of Emotional Stimuli on Putative Mirror Neuron Activity: A Transcranial Magnetic Stimulation Study.Basic and clinical neuroscience · 2025Article
- Investigating changes in the premotor cortex-derived frontal-striatal-thalamic subcircuit in attenuated psychosis syndrome.Brain imaging and behavior · 2024Article
- Affiliative touch, sense of self and psychosis.Frontiers in psychiatry · 2024Article
- Fibre density and fibre-bundle cross-section of the corticospinal tract are distinctly linked to psychosis-specific symptoms in antipsychotic-naïve patients with first-episode schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- Neural responses to biological motion distinguish autistic and schizotypal traits.Social cognitive and affective neuroscience · 2023Article
- The Transdiagnostic Relevance of Self-Other Distinction to Psychiatry Spans Emotional, Cognitive and Motor Domains.Frontiers in psychiatry · 2022Article
- Interpersonal Coordination in Schizophrenia: A Scoping Review of the Literature.Schizophrenia bulletin · 2021Article
- The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors.Translational psychiatry · 2021Article
- Linking RDoC and HiTOP: A new interface for advancing psychiatric nosology and neuroscience.Clinical psychology review · 2021Review
- Intrinsic Connectivity Patterns of Task-Defined Brain Networks Allow Individual Prediction of Cognitive Symptom Dimension of Schizophrenia and Are Linked to Molecular Architecture.Biological psychiatry · 2021Article
- Modality-specific dysfunctional neural processing of social-abstract and non-social-concrete information in schizophrenia.NeuroImage. Clinical · 2021Article
- Yoga and Spirituality in Mental Health: Illness to Wellness.Indian journal of psychological medicine · 2020Article
- Beneficial effects of omega-3 fatty acid supplementation in schizophrenia: possible mechanisms.Lipids in health and disease · 2020Review
- A sensorimotor control framework for understanding emotional communication and regulation.Neuroscience and biobehavioral reviews · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Dysfunctional mirror neuron activity (MNA) has been posited to underlie diverse symptoms of schizophrenia (e.g., ego-boundary disturbances, negative symptoms, social cognition impairments and catatonic symptoms). In this paper, we systematically review studies that have empirically compared putative MNA in schizophrenia patients and healthy subjects using different neurophysiological probes. Majority of the studies (n=9) reported reduced MNA in patients. Two each reported either increased MNA or mixed (both increased and decreased) results, while only one study reported normal findings. Reduced MNA was associated with greater negative symptoms and theory of mind deficits. The neurophysiological technique, task paradigms used, specific brain regions studied and laterality did not influence these findings. Further, we propose an overarching model to understand the heterogeneous symptom dimensions of schizophrenia, in which an inherent mirror system deficit underlying persistent negative symptoms, social cognition impairments and self-monitoring deficits triggers a pathological metaplastic reorganization of this system resulting in aberrant excessive MNA and the phasic catatonic symptoms, affective instability and hallucinations. Despite being preliminary in nature, evidence of abnormal MNA in schizophrenia reported necessitates more detailed investigation. Future research directions of using this model within the Research Domain Criteria framework of the National Institute of Mental Health are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.