Evidence map›Paper›PMID 25468180›Full record

ReviewSchizophrenia research2016

Behavioral sequelae of astrocyte dysfunction: focus on animal models of schizophrenia.

Meng Xia, Sofya Abazyan, Yan Jouroukhin, Mikhail Pletnikov

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Schizophrenia research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Abnormal neurobiochemical metabolites in the firstZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
  7. Review
  8. Review
  9. General Pathophysiology of Astroglia.Advances in experimental medicine and biology · 2019
    Review
  10. An Overview of Animal Models Related to Schizophrenia.Canadian journal of psychiatry. Revue canadienne de psychiatrie · 2019
    Review
  11. Review
  12. Article
  13. Self-injurious behaviours in rhesus macaques: Potential glial mechanisms.Journal of intellectual disability research : JIDR · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Meng XiaDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States; Preclinical College, Guangxi University of Chinese Medicine, Nanning, 530001 Guangxi Province, China; Chinese Medicine College, Hubei University for Nationalities, ENSHI, 445000 Hubei Province, China.
Sofya AbazyanDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States.
Yan JouroukhinDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States.
Mikhail PletnikovDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, United States; Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, United States; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, United States; Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, United States. Electronic address: mpletnik@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · US

Funding

Project 3P50MH094268 · NIMH · JOHNS HOPKINS UNIVERSITY · PI SAWA, AKIRA · 2011 to 2020
$19.9M
Mutant DISC 1 and Abnormal Neurodevelopment in Mental IllnessR01MH083728 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PLETNIKOV, MIKHAIL V · 2009 to 2020
$4.9M
NIMH NIH HHS P50 MH094268NIMH NIH HHS R01 MH083728
6 · The paper itself

Abstract

Astrocytes regulate multiple processes in the brain ranging from trophic support of developing neurons to modulation of synaptic neurotransmission and neuroinflammation in adulthood. It is, therefore, understandable that pathogenesis and pathophysiology of major psychiatric disorders involve astrocyte dysfunctions. Until recently, there has been the paucity of experimental approaches to studying the roles of astrocytes in behavioral disease. A new generation of in vivo models allows us to advance our understanding of the roles of astrocytes in psychiatric disorders. This review will evaluate the recent studies that focus on the contribution of astrocyte dysfunction to behavioral alterations pertinent to schizophrenia and will propose the possible solutions of the limitations of the existing approaches.

Indexed as

AstrocytesBehavior, AnimalDisease Models, AnimalInflammationSchizophreniaAnimalsHumansGlutamateNeuroinflammationNeuron–astrocyte interactionPsychiatric disordersTripartite synapse

Identifiers

PMID25468180
PMCPMC4439390
OpenAlexW2073995546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.