Evidence map›Paper›PMID 25468068›Full record

ReviewTrends in cell biology2015

Post-translational modifications of tubulin: pathways to functional diversity of microtubules.

Yuyu Song, Scott T Brady

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 223 papers.

0numbers the graph read from it
0cells of the map it votes in
223citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

223 citing papers in PubMed.

  1. Review
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  8. Amyloid Beta Oligomers as Early Triggers of Neuronal Cytoskeleton Dysfunction in Alzheimer's Disease.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
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  17. Review
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163 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yuyu SongYale School of Medicine, Department of Genetics and Howard Hughes Medical Institute, Boyer Center, 295 Congress Avenue, New Haven, CT 065105, USA.
Scott T BradyDepartment of Anatomy and Cell Biology, 808 S. Wood St., Rm 578 (M/C 512), University of Illinois at Chicago, Chicago, IL 60612, USA. Electronic address: stbrady@uic.edu.

Funding

Tau Conformation in Tauopathies and Neuronal FunctionR01NS082730 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BRADY, SCOTT THOMAS, KANAAN, NICHOLAS M · 2014 to 2023
$7.0M
MOLECULAR MECHANISMS OF AXONAL TRANSPORTR01NS023868 · NINDS · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI BRADY, SCOTT THOMAS · 1986 to 2010
$3.7M
REGULATION OF FAST AXONAL TRANSPORT DIABETIC NEUROPATHYR01NS041170 · NINDS · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI BRADY, SCOTT THOMAS · 2000 to 2004
$1.6M
PROPERTIES OF AXONAL TUBULIN RELATED TO NEURONAL GROWTHR01NS023320 · NINDS · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI BRADY, SCOTT THOMAS · 1985 to 2003
$1.0M
Molecular Mechanisms of Axonal TransportR56NS023868 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BRADY, SCOTT THOMAS · 2011 to 2011
$554k
Howard Hughes Medical InstituteNINDS NIH HHS NS023868NINDS NIH HHS NS041170NINDS NIH HHS R01 NS023320NINDS NIH HHS R01 NS023868NINDS NIH HHS R01 NS041170NINDS NIH HHS R01 NS082730NINDS NIH HHS R56 NS023868
6 · The paper itself

Abstract

Tubulin and microtubules are subject to a remarkable number of post-translational modifications. Understanding the roles these modifications play in determining the functions and properties of microtubules has presented a major challenge that is only now being met. Many of these modifications are found concurrently, leading to considerable diversity in cellular microtubules, which varies with development, differentiation, cell compartment, and cell cycle. We now know that post-translational modifications of tubulin affect, not only the dynamics of the microtubules, but also their organization and interaction with other cellular components. Many early suggestions of how post-translational modifications affect microtubules have been replaced with new ideas and even new modifications as our understanding of cellular microtubule diversity comes into focus.

Indexed as

Protein Processing, Post-TranslationalAnimalsHumansMicrotubulesTubulinTubulinacetylationdetyrosinationmicrotubulepolyaminationpolyglutamylationtubulin

Identifiers

PMID25468068
PMCPMC4344850

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.