Evidence map›Paper›PMID 25467987›Full record

ArticleNeuron2014

Adaptive training diminishes distractibility in aging across species.

Jyoti Mishra, Etienne de Villers-Sidani, Michael Merzenich, Adam Gazzaley

Open access · bronzeAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 2 syntheses or guidelines pooled it, 134 citations in OpenAlex.

  1. Pooled it
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  5. Musical Training Facilitates Exogenous Temporal Attention via Delta Phase Entrainment within a Sensorimotor Network.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
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  6. How musical rhythm training improves short-term memory for faces.Proceedings of the National Academy of Sciences of the United States of America · 2022
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  8. Closed-Loop Neurofeedback of α Synchrony during Goal-Directed Attention.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
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  16. Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Jyoti MishraDepartment of Neurology, Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: jyoti.mishra@ucsf.edu.
Etienne de Villers-SidaniDepartment of Neurology and Neurosurgery, McGill University, Montreal, QC H3A 2B4, Canada.
Michael MerzenichKeck Center for Integrative Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA.
Adam GazzaleyDepartment of Neurology, Physiology and Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA; Keck Center for Integrative Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA. Electronic address: adam.gazzaley@ucsf.edu.
University of California, San Francisco · USMcGill University · CA

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Neural Mechanisms Underlying Cognitive AgingR01AG030395 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAZZALEY, ADAM H · 2008 to 2012
$2.0M
Neural Mechanisms of Learning to Resolve Interference in Younger and Older AdultsR01AG040333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GAZZALEY, ADAM H · 2012 to 2016
$1.2M
FIC NIH HHS 5R24TW007988-05FIC NIH HHS R24 TW007988NIA NIH HHS 5R01AG030395NIA NIH HHS R01 AG030395NIA NIH HHS R01 AG040333NIA NIH HHS R01AG040333
6 · The paper itself

Abstract

Aging is associated with deficits in the ability to ignore distractions, which has not yet been remediated by any neurotherapeutic approach. Here, in parallel auditory experiments with older rats and humans, we evaluated a targeted cognitive training approach that adaptively manipulated distractor challenge. Training resulted in enhanced discrimination abilities in the setting of irrelevant information in both species that was driven by selectively diminished distraction-related errors. Neural responses to distractors in auditory cortex were selectively reduced in both species, mimicking the behavioral effects. Sensory receptive fields in trained rats exhibited improved spectral and spatial selectivity. Frontal theta measures of top-down engagement with distractors were selectively restrained in trained humans. Finally, training gains generalized to group and individual level benefits in aspects of working memory and sustained attention. Thus, we demonstrate converging cross-species evidence for training-induced selective plasticity of distractor processing at multiple neural scales, benefitting distractor suppression and cognitive control.

Indexed as

TeachingAdaptation, PhysiologicalAdultAgedAgingAnimalsAttentionAuditory CortexCohort StudiesEvoked PotentialsFemaleFood DeprivationHumansMaleMemory, Short-TermNeuropsychological Tests

Identifiers

PMID25467987
PMCPMC4264379
OpenAlexW1998742484

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.