ArticleNeuron2014
The balance between cytoplasmic and nuclear CaM kinase-1 signaling controls the operating range of noxious heat avoidance.
Article in Neuron, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 56 citations in OpenAlex.
- Starvation transforms signal encoding ineLife · 2026Article
- Calcineurin A/TAX-6 signaling inhibits noxious heat-evoked nuclear accumulation of CMK-1 in the FLP thermo-nociceptive neurons ofmicroPublication biology · 2026Article
- Conserved Calcineurin A splice variants regulate both constitutive and experience-dependent behaviors through tissue-specific signaling.PLoS genetics · 2025Article
- CaMK modulates sensory neural activity to control longevity and proteostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Excitation-transcription coupling, neuronal gene expression and synaptic plasticity.Nature reviews. Neuroscience · 2023Review
- Multisite regulation integrates multimodal context in sensory circuits to control persistent behavioral states in C. elegans.Nature communications · 2023Article
- Multiple antagonist calcium-dependent mechanisms control CaM kinase-1 subcellular localization in aeLife · 2023Article
- Distinct clusters of human pain gene orthologs in Caenorhabditis elegans regulate thermo-nociceptive sensitivity and plasticity.Genetics · 2023Article
- Article
- Molecular Mechanisms Underlying CaInternational journal of molecular sciences · 2022Review
- The Q-system: A Versatile Repressible Binary Expression System.Methods in molecular biology (Clifton, N.J.) · 2022Review
- The Q system for conditional gene expression is leaky and lacks dynamic range inmicroPublication biology · 2022Article
- CaeLife · 2021Article
- Signaling via the FLP-14/FRPR-19 neuropeptide pathway sustains nociceptive response to repeated noxious stimuli in C. elegans.PLoS genetics · 2021Article
- Article
- A system for the high-throughput analysis of acute thermal avoidance and adaptation inJournal of biological methods · 2020Article
- Identification of avoidance genes through neural pathway-specific forward optogenetics.PLoS genetics · 2019Article
- Neuro-genetic plasticity of Caenorhabditis elegans behavioral thermal tolerance.BMC neuroscience · 2019Article
- HowGenetics · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Through encounters with predators, competitors, and noxious stimuli, animals have evolved defensive responses that minimize injury and are essential for survival. Physiological adaptation modulates the stimulus intensities that trigger such nocifensive behaviors, but the molecular networks that define their operating range are largely unknown. Here, we identify a gain-of-function allele of the cmk-1 CaMKI gene in C. elegans and show that loss of the regulatory domain of the CaMKI enzyme produces thermal analgesia and shifts the operating range for nocifensive heat avoidance to higher temperatures. Such analgesia depends on nuclear CMK-1 signaling, while cytoplasmic CMK-1 signaling lowers the threshold for thermal avoidance. CMK-1 acts downstream of heat detection in thermal receptor neurons and controls neuropeptide release. Our results establish CaMKI as a key regulator of the operating range for nocifensive behaviors and suggest strategies for producing thermal analgesia through the regulation of CaMKI-dependent signaling.
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Registered trials
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