Evidence map›Paper›PMID 25467916›Full record

ArticleCell stem cell2015

Inhibition of pluripotency networks by the Rb tumor suppressor restricts reprogramming and tumorigenesis.

Michael S Kareta, Laura L Gorges, Sana Hafeez, Bérénice A Benayoun, Samuele Marro, Anne-Flore Zmoos, Matthew J Cecchini, Damek Spacek, Luis F Z Batista, Megan O'Brien and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
139citing papers in PubMed, 1 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

139 citing papers in PubMed, 1 synthesis or guideline pooled it, 198 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harbor perspectives in biology · 2026
    Article
  4. Article
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  7. Review
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  9. Article
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  11. Review
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  15. Coupling of stemness maintenance with cell cycle control in stem cells.Frontiers in cell and developmental biology · 2025
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

79 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 3 institutions in 2 countries.

Michael S KaretaDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA; Department of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
Laura L GorgesDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Sana HafeezDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
Bérénice A BenayounDepartment of Genetics, Stanford University, Stanford, CA 94305, USA; Paul F. Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.
Samuele MarroDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
Anne-Flore ZmoosDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Matthew J CecchiniLondon Regional Cancer Program, Children's Research Institute, Western University, London, ON N6A 4L6, Canada.
Damek SpacekDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Luis F Z BatistaDepartment of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
Megan O'BrienDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Yi-Han NgDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
Cheen Euong AngDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
Dedeepya VakaDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA.
Steven E ArtandiDepartment of Medicine, Stanford University, Stanford, CA 94305, USA; Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA.
Frederick A DickLondon Regional Cancer Program, Children's Research Institute, Western University, London, ON N6A 4L6, Canada.
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA 94305, USA; Paul F. Glenn Laboratories for the Biology of Aging, Stanford University, Stanford, CA 94305, USA.
Julien SageDepartment of Pediatrics, Stanford University, Stanford, CA 94305, USA; Department of Genetics, Stanford University, Stanford, CA 94305, USA. Electronic address: julsage@stanford.edu.
Marius WernigDepartment of Pathology, Stanford University, Stanford, CA 94305, USA; Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA 94305, USA. Electronic address: wernig@stanford.edu.
Stanford University · USStanford Medicine · USWestern University · CA

Funding

Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMAS A. RANDO · 2011 to 2026
$29.3M
Leveraging innovative technologies in basic and clinical cancer researchT32CA009302 · NCI · STANFORD UNIVERSITY · PI LAURA D ATTARDI, Aaron M Newman · 1985 to 2026
$19.1M
TUMOR BIOLOGYT32CA009151 · NCI · STANFORD UNIVERSITY · PI CLEARY, MICHAEL L · 1985 to 2014
$5.5M
The RB pathway in liver cancerR01CA114102 · NCI · STANFORD UNIVERSITY · PI SAGE, JULIEN · 2006 to 2016
$2.9M
Regulation of the Telomerase Protein Component In CancerR01CA125453 · NCI · STANFORD UNIVERSITY · PI ARTANDI, STEVEN E · 2006 to 2015
$2.2M
Canadian Institutes of Health ResearchNCI NIH HHS R01 CA114102NCI NIH HHS R01 CA125453NCI NIH HHS T32 CA009151NCI NIH HHS T32 CA09151NIA NIH HHS P01 AG036695
6 · The paper itself

Abstract

Mutations in the retinoblastoma tumor suppressor gene Rb are involved in many forms of human cancer. In this study, we investigated the early consequences of inactivating Rb in the context of cellular reprogramming. We found that Rb inactivation promotes the reprogramming of differentiated cells to a pluripotent state. Unexpectedly, this effect is cell cycle independent, and instead reflects direct binding of Rb to pluripotency genes, including Sox2 and Oct4, which leads to a repressed chromatin state. More broadly, this regulation of pluripotency networks and Sox2 in particular is critical for the initiation of tumors upon loss of Rb in mice. These studies therefore identify Rb as a global transcriptional repressor of pluripotency networks, providing a molecular basis for previous reports about its involvement in cell fate pliability, and implicate misregulation of pluripotency factors such as Sox2 in tumorigenesis related to loss of Rb function.

Indexed as

Cellular ReprogrammingAnimalsCarcinogenesisCell CycleChromatinFibroblastsHomeodomain ProteinsHumansInduced Pluripotent Stem CellsMiceNanog Homeobox ProteinOctamer Transcription Factor-3Protein BindingRepressor ProteinsRetinoblastoma ProteinSOXB1 Transcription FactorsChromatinHomeodomain ProteinsNanog Homeobox ProteinNanog protein, mouseOctamer Transcription Factor-3Repressor ProteinsRetinoblastoma ProteinSOXB1 Transcription Factors

Identifiers

PMID25467916
PMCPMC4389904
OpenAlexW2136792748

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.