Evidence map›Paper›PMID 25467810›Full record

ArticleClinical biomechanics (Bristol, Avon)2014

Asymmetrical pedaling patterns in Parkinson's disease patients.

Amanda L Penko, Joshua R Hirsch, Claudia Voelcker-Rehage, Philip E Martin, Gordon Blackburn, Jay L Alberts

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical biomechanics (Bristol, Avon), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
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  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Amanda L PenkoDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA; Cleveland FES Center, L. Stokes Cleveland VA Medical Center, Cleveland, OH, USA.
Joshua R HirschDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA.
Claudia Voelcker-RehageJacobs University, Bremen, Germany.
Philip E MartinIowa State University, Ames, IA, USA.
Gordon BlackburnDepartment of Preventive Cardiology, Cleveland Clinic, Cleveland, OH, USA.
Jay L AlbertsDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA; Center for Neurological Restoration, Cleveland Clinic, Cleveland, OH, USA; Cleveland FES Center, L. Stokes Cleveland VA Medical Center, Cleveland, OH, USA. Electronic address: albertj@ccf.org.
Cleveland Clinic · USConstructor University · DEIowa State University · US

Funding

The Cyclical Lower-extremity Exercise for Parkinson's TrialR01NS073717 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L. · 2011 to 2023
$4.8M
Effects of forced exercise training on Parkinson's motor functionR21HD056316 · NICHD · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L. · 2009 to 2010
$417k
NICHD NIH HHS R21 HD056316NICHD NIH HHS R21HD056316ANINDS NIH HHS R01 NS073717
6 · The paper itself

Abstract

backgroundApproximately 1.5 million Americans are affected by Parkinson's disease (Deponti et al., 2013) which includes the symptoms of postural instability and gait dysfunction. Currently, clinical evaluations of postural instability and gait dysfunction consist of a subjective rater assessment of gait patterns using items from the Unified Parkinson's Disease Rating Scale, and assessments can be insensitive to the effectiveness of medical interventions. Current research suggests the importance of cycling for Parkinson's disease patients, and while Parkinson's gait has been evaluated in previous studies, little is known about lower extremity control during cycling. The purpose of this study is to examine the lower extremity coordination patterns of Parkinson's patients during cycling.

methodsTwenty five participants, ages 44-72, with a clinical diagnosis of idiopathic Parkinson's disease participated in an exercise test on a cycle ergometer that was equipped with pedal force measurements. Crank torque, crank angle and power produced by right and left leg were measured throughout the test to calculate Symmetry Index at three stages of exercise (20 W, 60 W, maximum performance).

findingsDecreases in Symmetry Index were observed for average power output in Parkinson's patients as workload increased. Maximum power Symmetry Index showed a significant difference in symmetry between performance at both the 20 W and 60 W stage and the maximal resistance stage. Minimum power Symmetry Index did not show significant differences across the stages of the test. While lower extremity asymmetries were present in Parkinson's patients during pedaling, these asymmetries did not correlate to postural instability and gait dysfunction Unified Parkinson's Disease Rating Scale scores.

interpretationThis pedaling analysis allows for a more sensitive measure of lower extremity function than the Unified Parkinson's Disease Rating Scale and may help to provide unique insight into current and future lower extremity function.

Indexed as

AdultAgedBicyclingExercise TestFemaleHumansKineticsLegLower ExtremityMaleMiddle AgedMuscle StrengthParkinson DiseasePostural BalanceParkinson's diseasePedalingPostural instabilityUPDRS

Identifiers

PMID25467810
PMCPMC4362538
OpenAlexW2020734995

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.