Trial reportEuropean archives of psychiatry and clinical neuroscience2015
Reduced volume of the nucleus accumbens in heroin addiction.
Trial report in European archives of psychiatry and clinical neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The trial behind it
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Who cites it
41 citing papers in PubMed, 80 citations in OpenAlex.
- Differences in anxiety, depression, and heart rate variability between patients with methamphetamine use disorder and heroin use disorder patients on methadone maintenance treatment.BMC psychiatry · 2026Article
- Repetitive transcranial magnetic stimulation reduces nicotine dependence and potentially modulates white matter microstructure in smokers: a pilot study by diffusion spectrum imaging.Frontiers in neurology · 2025Article
- Brain microRNA profiles after exposure to heroin in rats.Experimental brain research · 2024Article
- Neurocognitive performance of patients undergoing intravenous versus oral opioid agonist treatment: a prospective multicenter study on three-month treatment effects.Frontiers in psychiatry · 2024Article
- Common and distinct drug cue reactivity patterns associated with cocaine and heroin: An fMRI meta-analysis.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A Systematic Review of Structural and Functional MRI Studies Investigating Social Networking Site Use.Brain sciences · 2023Review
- Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders.Brain : a journal of neurology · 2023Article
- Effects of current smoking severity on brain gray matter volume in opioid use disorder - a voxel-based morphometry study.The American journal of drug and alcohol abuse · 2023Article
- Ribosomal DNA transcription is increased in the left nucleus accumbens of heroin-dependent males.European archives of psychiatry and clinical neuroscience · 2022Article
- The hypertrophic amygdala shape associated with anxiety in patients with primary dysmenorrhea during pain-free phase: insight from surface-based shape analysis.Brain imaging and behavior · 2022Article
- Recovery of superior frontal gyrus cortical thickness and resting-state functional connectivity in abstinent heroin users after 8 months of follow-up.Human brain mapping · 2022Article
- Hypoperfusion in nucleus accumbens in chronic migraine using 3D pseudo-continuous arterial spin labeling imaging MRI.The journal of headache and pain · 2022Article
- Shapes of subcortical structures in adolescents with and without familial history of substance use disorder.Human brain mapping · 2022Article
- Striatal resting-state connectivity after long-term diacetylmorphine treatment in opioid-dependent patients.Brain communications · 2022Article
- Volumetric data of normal nucleus accumbens from magnetic resonance imaging scans.Medicine and pharmacy reports · 2021Article
- Impaired working memory performance in opioid-dependent patients is related to reduced insula gray matter volume: a voxel-based morphometric study.European archives of psychiatry and clinical neuroscience · 2021Article
- Reduced habenular volumes and neuron numbers in male heroin addicts: a post-mortem study.European archives of psychiatry and clinical neuroscience · 2021Article
- The molecular neurobiology and neuropathology of opioid use disorder.Current research in neurobiology · 2021Article
- Gray matter alteration in heroin-dependent men: An atlas-based magnetic resonance imaging study.Psychiatry research. Neuroimaging · 2020Article
- Brain activity and transcriptional profiling in mice under chronic jet lag.Scientific data · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neural mechanisms of heroin addiction are still incompletely understood, even though modern neuroimaging techniques offer insights into disease-related changes in vivo. While changes on cortical structure have been reported in heroin addiction, evidence from subcortical areas remains underrepresented. Functional imaging studies revealed that the brain reward system and particularly the nucleus accumbens (NAcc) play a pivotal role in the pathophysiology of drug addiction. The aim of this study was to investigate whether there was a volume difference of the NAcc in heroin addiction in comparison to healthy controls. A further aim was to correlate subcortical volumes with clinical measurements on negative affects in addiction. Thirty heroin-dependent patients under maintenance treatment with diacetylmorphine and twenty healthy controls underwent structural MRI scanning at 3T. Subcortical segmentation analysis was performed using FMRIB's Integrated Registration and Segmentation Tool function of FSL. The State-Trait Anxiety Inventory and the Beck Depression Inventory were used to assess trait anxiety and depressive symptoms, respectively. A decreased volume of the left NAcc was observed in heroin-dependent patients compared to healthy controls. Depression score was negatively correlated with left NAcc volume in patients, whereas a positive correlation was found between the daily opioid dose and the volume of the right amygdala. This study indicates that there might be structural differences of the NAcc in heroin-dependent patients in comparison with healthy controls. Furthermore, correlations of subcortical structures with negative emotions and opioid doses might be of future relevance for the investigation of heroin addiction.
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