ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015
Hyponatremia and osteoporosis: insights from the Danish National Patient Registry.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04588207 (Urea for Chronic Hyponatremia), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Urea for Chronic Hyponatremia: A Pilot Study
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Hyponatremia and aging-related diseases: key player or innocent bystander? A systematic review.Systematic reviews · 2023Pooled it
- Hyponatraemia in Neck of Femur Fracture: A Narrative Review of Epidemiology, Pathophysiology, and Outcomes.Geriatrics (Basel, Switzerland) · 2026Review
- Pathophysiology, symptoms, outcomes, and evaluation of hyponatremia: comprehension and best clinical practice.Clinical and experimental nephrology · 2025Review
- The Influence of Hyponatremia and Hypokalemia on the Risk of Fractures in Various Anatomical Regions among Adult Trauma Patients: A Propensity Score-Matched Analysis.Diagnostics (Basel, Switzerland) · 2024Article
- Effect of denosumab on bone mineral density in a postmenopausal osteoporotic woman with prolonged chronic mild hyponatremia.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2023Article
- Association of hyponatremia with bone mineral density and fractures: a narrative review.Therapeutic advances in endocrinology and metabolism · 2023Review
- Assocıatıons between mıld hyponatremıa and gerıatrıc syndromes ın outpatıent settıngs.International urology and nephrology · 2021Article
- The effect of normalization of sodium on bone turnover markers in patients with epilepsy. A randomized single-blinded placebo-controlled trial.Contemporary clinical trials communications · 2020Article
- Chronic hyponatremia and association with osteoporosis among a large racially/ethnically diverse population.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019Article
- Association between diuretic use and the risk of vertebral fracture after stroke: a population-based retrospective cohort study.BMC musculoskeletal disorders · 2019Article
- Hyponatremia and the risk of kidney stones: A matched case-control study in a large U.S. health system.PloS one · 2018Article
- Clinical fracture risk evaluated by hierarchical agglomerative clustering.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- Hyponatremia and bone disease.Reviews in endocrine & metabolic disorders · 2017Review
- Hyponatremia and Bone Fractures: An Intriguing and Often Overlooked Association.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2017Article
- Article
- Hyponatremia, a risk factor for osteoporosis and fractures in women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Mild Chronic Hyponatremia in the Ambulatory Setting: Significance and Management.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Hyponatremia Is Associated With Increased Osteoporosis and Bone Fractures in a Large US Health System Population.The Journal of clinical endocrinology and metabolism · 2015Article
- Asymptomatic hyponatremia: is it time to abandon this entity?Journal of nephropharmacology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe association between hyponatremia and osteoporosis was evaluated in humans. A significant association was found between low sodium levels, lower bone mineralization in the hip, and with several common conditions. Hyponatremia could be used as a marker of osteoporosis and systemic disease.
introductionThe objective of this study was to evaluate the association between hyponatremia and osteoporosis in humans through a cross-sectional study.
methodsPatient information was gathered from regional and national Danish patient databases, both in- and outpatient settings, from 2004 to 2011. Patients with dual-energy x-ray absorptiometry (DXA) scans performed within this time were included if accompanied [Na+] was measured within 14 days prior or past the scan date. A total of 1575 patients were included.
resultsA total of 104 patients were hyponatremic (6.6 %). Total hip and lumbar spine bone mineral content (BMC) and densities (BMD) and T-scores were all significantly lower with hyponatremia. The odds ratio (OR) of osteoporosis significantly increased among hyponatremic patients at both total hip (unadjusted OR = 2.17, 95% CI = [1.40-3.34], p < .05) and lumbar spine (unadjusted OR = 1.83, 95% CI = [1.20-2.80], p < .05) regions. Dose-response found between increasing [Na+] and increasing total hip BMC (slope .174, adjusted p < .05), BMD (slope .004, adjusted p < .05), and T-score (slope .034, adjusted p < .05). Systemic disease was more prevalent in hyponatremia.
conclusionThe presence of hyponatremia increases the risk of concurrent osteoporosis at both the total hip and lumbar spine in humans. Hyponatremia could be used a screening tool and marker of secondary osteoporosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.