SynthesisJournal of applied oral science : revista FOB
Antibacterial effect of calcium hydroxide combined with chlorhexidine on Enterococcus faecalis: a systematic review and meta-analysis.
Synthesis in Journal of applied oral science : revista FOB. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Influence of intracanal medicaments on the periodontal and periapical healing in concurrent endodontic-periodontal lesions with/without communication: a systematic review and meta-analysis.Clinical oral investigations · 2023Pooled it
- Comparative antimicrobial efficacy of three intracanal medicaments in an in vitro Enterococcus faecalis root canal infection model.BMC oral health · 2026Article
- Pull-off bond strength of orthodontic molar bands cemented to enamel with novel calcium silicate, glass ionomer, and zinc phosphate cement.Biomaterial investigations in dentistry · 2026Article
- Antimicrobial effectiveness of intracanal medicaments againstFrontiers in oral health · 2026Review
- Antimicrobial activity of Salvia spinosa against Enterococcus faecalis causing endodontic infections: an in-vitro, ex-vivo, and in-silico study.BMC complementary medicine and therapies · 2025Article
- Influence of number of visits on the outcome of endodontic treatment.Journal of conservative dentistry and endodontics · 2024Review
- Comparative evaluation of antibacterial efficacy ofJournal of conservative dentistry and endodontics · 2024Article
- Mechanistic Insight into the Anti-Bacterial/Anti-Biofilm Effects of Low Chlorhexidine Concentrations onMicroorganisms · 2024Article
- Article
- Diacetylcurcumin: a novel strategy againstFuture microbiology · 2024Article
- Efficacy of 5% Aminolaevulinic Acid and Red Light onGels (Basel, Switzerland) · 2023Article
- 5-Aminolevulinic Acid and Red Led in Endodontics: A Narrative Review and Case Report.Gels (Basel, Switzerland) · 2022Article
- Photocrosslinkable methacrylated gelatin hydrogel as a cell-friendly injectable delivery system for chlorhexidine in regenerative endodontics.Dental materials : official publication of the Academy of Dental Materials · 2022Article
- The effect of different intracanal medicaments on the dislodgement resistance of mineral trioxide aggregate.BMC oral health · 2022Article
- How Adding Chlorhexidine or Metallic Nanoparticles Affects the Antimicrobial Performance of Calcium Hydroxide Paste as an Intracanal Medication: An In Vitro Study.Antibiotics (Basel, Switzerland) · 2021Article
- Silver nanoparticles in endodontics: recent developments and applications.Restorative dentistry & endodontics · 2021Review
- Article
- In Vitro Development of a New Sponge-Based Delivery System for Intracanal Antimicrobial Administration in Endodontic Treatment.Journal of clinical medicine · 2021Article
- Article
- Intratubular decontamination ability and physicochemical properties of calcium hydroxide pastes.Clinical oral investigations · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveEnterococcus faecalis (E. faecalis) is the most frequently isolated strain in failed endodontic therapy cases since it is resistant to calcium hydroxide (CH). Whether a combination of CH and chlorhexidine (CHX) is more effective than CH alone against E. faecalis is a matter of controversy. Thus, the aim of this study was to conduct a systematic review and meta-analysis of the literature. MATERIAL AND
methodsA comprehensive search in PubMed, EMbase, EBSCOhost, The Cochrane Library, SciELO, and BBO databases, Clinical trials registers, Open Grey, and conference proceedings from the earliest available date to February 1, 2013 was carried out and the relevant articles were identified by two independent reviewers. Backward and forward search was performed and then inclusion and exclusion criteria were applied. The included studies were divided into "comparisons" according to the depth of sampling and dressing period of each medicament. Meta-analysis was performed using Stata software 10.0. The level of significance was set at 0.05.
resultsEighty-five studies were retrieved from databases and backward/forward searches. Fortyfive studies were considered as relevant (5 in vivo, 18 in vitro, 18 ex vivo, and 4 review articles). Nine studies were included for meta-analysis. Inter-observer agreement (Cohen kappa) was 0.93. The included studies were divided into 21 comparisons for meta-analysis. Chi-square test showed the comparisons were heterogeneous (p<0.001). Random effect model demonstrated no significant difference between CH/CHX mixture and CH alone in their effect on E. faecalis (p=0.115).
conclusionsAccording to the evidence available now, mixing CH with CHX does not significantly increase the antimicrobial activity of CH against E. faecalis. It appears that mixing CH with CHX does not improve its ex vivo antibacterial property as an intracanal medicament against E. faecalis. Further in vivo studies are necessary to confirm and correlate the findings of this study with the clinical outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.