Evidence map›Paper›PMID 25466277›Full record

ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016

Multilayer scaffolds in orthopaedic tissue engineering.

Kivanc Atesok, M Nedim Doral, Jon Karlsson, Kenneth A Egol, Laith M Jazrawi, Paulo G Coelho, Amaury Martinez, Tomoyuki Matsumoto, Brett D Owens, Mitsuo Ochi and 5 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. A Systematic Review of Tissue Engineering Scaffold in Tendon Bone HealingFrontiers in bioengineering and biotechnology · 2021
    Pooled it
  2. Trial
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  8. Article
  9. Article
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  12. Article
  13. Article
  14. Porous Scaffold Design for Additive Manufacturing in Orthopedics: A Review.Frontiers in bioengineering and biotechnology · 2020
    Review
  15. 3D Bioprinting: from Benches to Translational Applications.Small (Weinheim an der Bergstrasse, Germany) · 2019
    Review
  16. Article
  17. Tissue Engineering for the Temporomandibular Joint.Advanced healthcare materials · 2019
    Review
  18. Article
  19. Three-Dimensional Bioprinting Strategies for Tissue Engineering.Cold Spring Harbor perspectives in medicine · 2018
    Review
  20. Inverse Opal Scaffolds and Their Biomedical Applications.Advanced materials (Deerfield Beach, Fla.) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kivanc AtesokSports Medicine and Shoulder Service, Hospital for Special Surgery, 525 East 71st Street, New York, NY, 10021, USA.
M Nedim DoralDepartment of Orthopaedics and Traumatology, Hacettepe University School of Medicine, 06100, Sihhiye, Ankara, Turkey.
Jon KarlssonDepartment of Orthopaedics, Sahlgrenska University Hospital, Sahlgrenska Academy, Gothenburg University, 431 80, Molndal, Sweden.
Kenneth A EgolDepartment of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 303 2nd Avenue, New York, NY, 10003, USA.
Laith M JazrawiCenter for Musculoskeletal Care, NYU Hospital for Joint Diseases, 333 east 38th street, New York, NY, 10016, USA.
Paulo G CoelhoDepartment of Periodontology and Implant Dentistry, New York University College of Dentistry, 345 east 24th street Room 804s, New York, NY, 10010, USA.
Amaury MartinezCenter for Musculoskeletal Care, NYU Hospital for Joint Diseases, 333 east 38th street, New York, NY, 10016, USA.
Tomoyuki MatsumotoDepartment of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, 650-0017, Japan.
Brett D OwensOrthopaedic Surgery Service, Keller Army Hospital, 900 Washington Rd, West Point, New York, NY, 10996, USA.
Mitsuo OchiDepartment of Orthopaedic Surgery, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minamimi-ku, Hiroshima, 734-8551, Japan.
Shepard R HurwitzDepartment of Orthopaedic Surgery, University of North Carolina, Chapel Hill, NC, USA.
Anthony AtalaWake Forest Institute for Regenerative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Freddie H FuDepartment of Orthopaedic Surgery, University of Pittsburgh School of Medicine, 3471 Fifth Avenue, Suite 1011, Pittsburgh, PA, 15213, USA.
Helen H LuDepartment of Biomedical Engineering, Columbia University, New York, NY, 10016, USA.
Scott A RodeoSports Medicine and Shoulder Service, Hospital for Special Surgery, 525 East 71st Street, New York, NY, 10021, USA. RodeoS@HSS.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to summarize the recent developments in the field of tissue engineering as they relate to multilayer scaffold designs in musculoskeletal regeneration.

methodsClinical and basic research studies that highlight the current knowledge and potential future applications of the multilayer scaffolds in orthopaedic tissue engineering were evaluated and the best evidence collected. Studies were divided into three main categories based on tissue types and interfaces for which multilayer scaffolds were used to regenerate: bone, osteochondral junction and tendon-to-bone interfaces.

resultsIn vitro and in vivo studies indicate that the use of stratified scaffolds composed of multiple layers with distinct compositions for regeneration of distinct tissue types within the same scaffold and anatomic location is feasible. This emerging tissue engineering approach has potential applications in regeneration of bone defects, osteochondral lesions and tendon-to-bone interfaces with successful basic research findings that encourage clinical applications.

conclusionsPresent data supporting the advantages of the use of multilayer scaffolds as an emerging strategy in musculoskeletal tissue engineering are promising, however, still limited. Positive impacts of the use of next generation scaffolds in orthopaedic tissue engineering can be expected in terms of decreasing the invasiveness of current grafting techniques used for reconstruction of bone and osteochondral defects, and tendon-to-bone interfaces in near future.

Indexed as

Bone and BonesCartilageTendonsTissue ScaffoldsHumansOrthopedicsRegenerationTissue EngineeringInterface tissue regenerationMultilayer scaffoldsMulti-lineage cell differentiationOrthopaedic tissue engineering

Identifiers

PMID25466277

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.