ArticleNature communications2014
Observing classical nucleation theory at work by monitoring phase transitions with molecular precision.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Theoretical Perspectives for Biomolecular Crystallization Prediction.Advances in biochemical engineering/biotechnology · 2026Review
- Gluebodies Offer a Route To Improve Crystal Reliability and Diversity through Transferable Nanobody Mutations That Introduce Constitutive Close Contacts.ACS central science · 2025Article
- An Extended Energy-Biased Aggregation-Volume-Bias Monte Carlo (EB-AVBMC) Method for Nucleation Simulation of a Reactive Water Potential.Journal of chemical theory and computation · 2025Article
- Resistive Pulse Sensing of Pre-Nucleation Activities during Single-Entity Lysozyme Crystallization on Single Nanopipettes.Sensors and actuators reports · 2025Article
- Solid-Liquid Interfacial Free Energy from Computer Simulations: Challenges and Recent Advances.Chemical reviews · 2025Review
- Gypsum heterogenous nucleation pathways regulated by surface functional groups and hydrophobicity.Nature communications · 2025Article
- Hydroxide films on mica form charge-stabilized microphases that circumvent nucleation barriers.Science advances · 2022Article
- Online Monitoring of the Concentrations of Amorphous and Crystalline Mesoscopic Species Present in Solution.Crystal growth & design · 2022Article
- An investigation of the kinetics and thermodynamics of NaCl nucleation through composite clusters.PNAS nexus · 2022Article
- Rotational dynamics and transition mechanisms of surface-adsorbed proteins.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Accounting for the Presence of Molecular Clusters in Modeling and Interpreting Nucleation and Growth.Crystal growth & design · 2022Article
- Temperature-dependent kinetic pathways of heterogeneous ice nucleation competing between classical and non-classical nucleation.Nature communications · 2021Article
- Nucleation of protein mesocrystals via oriented attachment.Nature communications · 2021Article
- Real-time monitoring of crystallization from solution by using an interdigitated array electrode sensor.Nanoscale horizons · 2021Article
- Atomic mechanism of metal crystal nucleus formation in a single-walled carbon nanotube.Nature chemistry · 2020Article
- Predicting heterogeneous ice nucleation with a data-driven approach.Nature communications · 2020Article
- A bacterial surface layer protein exploits multistep crystallization for rapid self-assembly.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Multistep nucleation and growth mechanisms of organic crystals from amorphous solid states.Nature communications · 2019Article
- Article
- -60 °C solution synthesis of atomically dispersed cobalt electrocatalyst with superior performance.Nature communications · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is widely accepted that many phase transitions do not follow nucleation pathways as envisaged by the classical nucleation theory. Many substances can traverse intermediate states before arriving at the stable phase. The apparent ubiquity of multi-step nucleation has made the inverse question relevant: does multistep nucleation always dominate single-step pathways? Here we provide an explicit example of the classical nucleation mechanism for a system known to exhibit the characteristics of multi-step nucleation. Molecular resolution atomic force microscopy imaging of the two-dimensional nucleation of the protein glucose isomerase demonstrates that the interior of subcritical clusters is in the same state as the crystalline bulk phase. Our data show that despite having all the characteristics typically associated with rich phase behaviour, glucose isomerase 2D crystals are formed classically. These observations illustrate the resurfacing importance of the classical nucleation theory by re-validating some of the key assumptions that have been recently questioned.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.