ArticleDong wu xue yan jiu = Zoological research2014
Experimental infection of tree shrews (Tupaia belangeri) with Coxsackie virus A16.
Article in Dong wu xue yan jiu = Zoological research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- A lethal juvenile mouse model for the evaluation of antiviral reagents against coxsackievirus A4.iScience · 2025Article
- Advances in viral encephalitis: Viral transmission, host immunity, and experimental animal models.Zoological research · 2023Review
- A mouse-adapted CVA6 strain exhibits neurotropism and triggers systemic manifestations in a novel murine model.Emerging microbes & infections · 2022Article
- Tree Shrew Cells Transduced with Human CD4 and CCR5 Support Early Steps of HIV-1 Replication, but Viral Infectivity Is Restricted by APOBEC3.Journal of virology · 2021Article
- A hSCARB2-transgenic mouse model for Coxsackievirus A16 pathogenesis.Virology journal · 2021Article
- Host Diversity and Potential Transmission Pathways of SARS-CoV-2 at the Human-Animal Interface.Pathogens (Basel, Switzerland) · 2021Review
- A novel orally infected hamster model for Coxsackievirus A16 hand-foot-and-mouth disease and encephalomyelitis.Laboratory investigation; a journal of technical methods and pathology · 2020Article
- Isolation and identification of two new strains of mammalian orthoreovirus from Chinese tree shrews.Archives of virology · 2020Article
- Pathogenesis and Immune Response Caused by Vector-Borne and Other Viral Infections in aMicroorganisms · 2019Review
- Chromosomal level assembly and population sequencing of the Chinese tree shrew genome.Zoological research · 2019Article
- The tree shrew as a model for infectious diseases research.Journal of thoracic disease · 2018Review
- CircRNAs in the tree shrew (Aging · 2018Article
- Tree shrew (Zoological research · 2017Review
- Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring.Cell research · 2017Article
- [Study of the Changes on Tree Shrew Bronchial Epithelium Induced by Xuanwei Bituminous Coal Dust].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coxsackie virus A16 (CA16) is commonly recognized as one of the main human pathogens of hand-foot-mouth disease (HFMD). The clinical manifestations of HFMD include vesicles of hand, foot and mouth in young children and severe inflammatory CNS lesions. In this study, experimentally CA16 infected tree shrews (Tupaia belangeri) were used to investigate CA16 pathogenesis. The results showed that both the body temperature and the percentages of blood neutrophilic granulocytes / monocytes of CA16 infected tree shrews increased at 4-7 days post infection. Dynamic distributions of CA16 in different tissues and stools were found at different infection stages. Moreover, the pathological changes in CNS and other organs were also observed. These findings indicate that tree shrews can be used as a viable animal model to study CA16 infection.
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