ArticleBMC complementary and alternative medicine2014
Experimental assessment of antidiarrheal and antisecretory activity of 80% methanolic leaf extract of Zehneria scabra in mice.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed.
- Integrated In Vivo, In Vitro, and In Silico Evaluation of Spermacoce ocymoides Methanolic Extract for Antidiarrheal, Thrombolytic, and Antiarthritic Activities.Cell biochemistry and biophysics · 2026Article
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- Isolation, Structure Elucidation, and Bioactivity Evaluation of Two Alkaloids FromFood science & nutrition · 2024Article
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- Evaluation of the antidiarrheal activity of the 80% hydromethanolic crude extract and solvent fractions ofFrontiers in pharmacology · 2024Article
- Antidiarrheal activities of methanolic crude extract and solvent fractions of the root ofHeliyon · 2023Article
- Ethanol Extract of Glycyrrhiza uralensis Fisch: Antidiarrheal Activity in Mice and Contraction Effect in Isolated Rabbit Jejunum.Chinese journal of integrative medicine · 2023Article
- Review of Medicinal Plants Traditionally Used to Treat Diarrhea by the People in the Amhara Region of Ethiopia.Evidence-based complementary and alternative medicine : eCAM · 2023Review
- The Detailed Pharmacodynamics of the Gut Relaxant Effect and GC-MS Analysis of theMolecules (Basel, Switzerland) · 2022Article
- Insecticidal effects of some selected plant extracts against Anopheles stephensi (Culicidae: Diptera).Malaria journal · 2022Article
- Dual Inhibition of Phosphodiesterase and CaPlants (Basel, Switzerland) · 2022Article
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- Evaluation of the antidiarrheal activity of 80% methanol extract and solvent fractions of the leaf of Bersama abyssinica fresen (Melianthaceae) in mice.BMC complementary medicine and therapies · 2022Article
- Antidiarrheal and Antisecretory Effect of 80% Hydromethanolic Leaf Extract ofBiochemistry research international · 2022Article
- Article
- Chemico-Biological Profiling ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Evaluation of Antidiarrheal Activity of 80% Methanol Extract and Solvent Fractions of the Leaves ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Antisecretory and Spasmolytic Activities of Aqueous and Ethanolic Stem Bark Extracts ofBioMed research international · 2022Article
- Evaluation of Antiplasmodial Activity of Hydroalcoholic Crude Extract and Solvent Fractions ofInfection and drug resistance · 2021Article
- Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2021Article
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4 authors.
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Abstract
backgroundThe leaf of Zehneria scabra is traditionally used for the management of diarrhea in Ethiopia. Its use, however, has not been scientifically validated for safety and efficacy. The aim of this study was to investigate antidiarrheal and antisecretory effects of hydroalcolic leaf extract of Z. scabra in mice models.
methodsFor each of antidiarrheal, gastrointestinal motility and antisecretory activity study Swiss albino mice were divided in to five groups. Group I was treated as control group and received 10 ml/kg of 2% Tween-80 orally; Group II served as a positive control and took standard drug in each of the experiments orally; Group III, IV and V were test groups which received the methanolic extract orally at 100, 200 and 400 mg/kg, respectively. Depending on the model total weight of fecal output, total weight of wet feces, total number of fecal output, number of wet faeces, length of intestinal transit and intestinal weight were collected. Finally, data were analyzed using one-way ANOVA followed by Tukey's post test.
resultIn castor oil induced diarrhea model, the extract dose produced a significant reduction in mean stool score (1.94 ± 0.102) at 200 mg/kg. Moreover, the 100, 200, and 400 mg/kg doses inhibited stool frequency by 40, 45 and 55%, respectively. All test doses of extract and loperamide (3mg/kg) reduced fecal fluid content significantly (p<0.01). The 100 mg/kg dose of extract produced 25.74% reduction of fluid content (p<0.001) while both 200 and 400 mg/kg showed 29.70 % (p<0.001) compared to negative control group.
conclusionThe extract of Zehineria scabra showed antidiarrheal and antisecretory activity in mice model. Moreover, the extract found to be safe at dose of 2000mg/kg in mice model. The findings suggest the validity of the acclaimed effect of Zehineria scabra as antidiarrheal agent in Ethiopian traditional herbal medicine.
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