Evidence map›Paper›PMID 25464850›Full record

ArticleCell reports2014

Telomere elongation and naive pluripotent stem cells achieved from telomerase haplo-insufficient cells by somatic cell nuclear transfer.

Li-Ying Sung, Wei-Fang Chang, Qian Zhang, Chia-Chia Liu, Jun-Yang Liou, Chia-Chun Chang, Huan Ou-Yang, Renpeng Guo, Haifeng Fu, Winston T K Cheng and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Li-Ying SungInstitute of Biotechnology, National Taiwan University, Taipei, 106 Taiwan, ROC; Agricultural Biotechnology Research Center, Academia Sinica, Taipei, 115 Taiwan, ROC; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, 100 Taiwan, ROC.
Wei-Fang ChangInstitute of Biotechnology, National Taiwan University, Taipei, 106 Taiwan, ROC.
Qian ZhangState Key Laboratory of Medicinal Chemical Biology and Collaborative Innovation Center for Biotherapy, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin 300071, China.
Chia-Chia LiuInstitute of Biotechnology, National Taiwan University, Taipei, 106 Taiwan, ROC; Institute of Cellular and System Medicine, National Health Research Institutes, Zhunan, 350 Taiwan, ROC.
Jun-Yang LiouInstitute of Cellular and System Medicine, National Health Research Institutes, Zhunan, 350 Taiwan, ROC.
Chia-Chun ChangInstitute of Biotechnology, National Taiwan University, Taipei, 106 Taiwan, ROC.
Huan Ou-YangInstitute of Biotechnology, National Taiwan University, Taipei, 106 Taiwan, ROC.
Renpeng GuoState Key Laboratory of Medicinal Chemical Biology and Collaborative Innovation Center for Biotherapy, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin 300071, China.
Haifeng FuState Key Laboratory of Medicinal Chemical Biology and Collaborative Innovation Center for Biotherapy, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin 300071, China.
Winston T K ChengInstitute of Biotechnology, National Taiwan University, Taipei, 106 Taiwan, ROC; Department of Animal Science and Biotechnology, Tunghai University, Taichung, 407 Taiwan, ROC.
Shih-Torng DingInstitute of Biotechnology, National Taiwan University, Taipei, 106 Taiwan, ROC.
Chuan-Mu ChenDepartment of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, Taichung, 402 Taiwan, ROC; Rong-Hsing Translational Medicine Center and iEGG Center, National Chung Hsing University, Taichung, 402 Taiwan, ROC.
Maja OkukaDepartment of Obstetrics and Gynecology, University of South Florida College of Medicine, Tampa, FL 33612, USA.
David L KeefeDepartment of Obstetrics and Gynecology, New York University Langone Medical Center, New York, NY 10016, USA.
Y Eugene ChenCenter for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
Lin LiuState Key Laboratory of Medicinal Chemical Biology and Collaborative Innovation Center for Biotherapy, Department of Cell Biology and Genetics, College of Life Sciences, Nankai University, Tianjin 300071, China. Electronic address: liulin@nankai.edu.cn.
Jie XuCenter for Advanced Models for Translational Sciences and Therapeutics, University of Michigan Medical Center, Ann Arbor, MI 48109, USA. Electronic address: jiex@umich.edu.
National Taiwan University · TWNankai University · CNMichigan Center for Translational Pathology · USNational Health Research Institutes · TWNYU Langone Health · USUniversity of South Florida · US

Funding

Restoration dynamics of Xp chromosomes in cloned bovine embryosR03HD053066 · NICHD · EVERGEN BIOTECHNOLOGIES, INC. · PI XU, JIE · 2007 to 2008
$138k
NICHD NIH HHS R03 HD053066
6 · The paper itself

Abstract

Haplo-insufficiency of telomerase genes in humans leads to telomere syndromes such as dyskeratosis congenital and idiopathic pulmonary fibrosis. Generation of pluripotent stem cells from telomerase haplo-insufficient donor cells would provide unique opportunities toward the realization of patient-specific stem cell therapies. Recently, pluripotent human embryonic stem cells (ntESCs) have been efficiently achieved by somatic cell nuclear transfer (SCNT). We tested the hypothesis that SCNT could effectively elongate shortening telomeres of telomerase haplo-insufficient cells in the ntESCs with relevant mouse models. Indeed, telomeres of telomerase haplo-insufficient (Terc(+/-)) mouse cells are elongated in ntESCs. Moreover, ntESCs derived from Terc(+/-) cells exhibit naive pluripotency as evidenced by generation of Terc(+/-) ntESC clone pups by tetraploid embryo complementation, the most stringent test of naive pluripotency. These data suggest that SCNT could offer a powerful tool to reprogram telomeres and to discover the factors for robust restoration of telomeres and pluripotency of telomerase haplo-insufficient somatic cells.

Indexed as

AnimalsCell DifferentiationCells, CulturedFemaleHaploinsufficiencyInduced Pluripotent Stem CellsMaleMice, Inbred C57BLMice, KnockoutNuclear Transfer TechniquesTelomeraseTelomereTelomere HomeostasisTelomerase

Identifiers

PMID25464850
PMCPMC4268138
OpenAlexW2171975889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.