ArticleCell reports2014
A rare human syndrome provides genetic evidence that WNT signaling is required for reprogramming of fibroblasts to induced pluripotent stem cells.
Article in Cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00691223 (Pathogenesis of Focal Dermal Hypoplasia or Goltz Syndrome and Related Disorders), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pathogenesis of Focal Dermal Hypoplasia or Goltz Syndrome and Related Disorders
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction.Stem cell reports · 2025Article
- Chromosome-level genome assembly and single-cell analysis unveil molecular mechanisms of arm regeneration in the ophiuroid Ophiura sarsii vadicola.Genome biology · 2025Article
- Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress.Nature communications · 2024Article
- Emerging roles of mitochondrial functions and epigenetic changes in the modulation of stem cell fate.Cellular and molecular life sciences : CMLS · 2024Review
- Cancer cells as a new source of induced pluripotent stem cells.Stem cell research & therapy · 2022Review
- Enrichment and Detection of Wnt Proteins from Cell Culture Media.Methods in molecular biology (Clifton, N.J.) · 2022Article
- CBP-mediated Wnt3a/β-catenin signaling promotes cervical oncogenesis initiated by Piwil2.Neoplasia (New York, N.Y.) · 2021Article
- Selective activation of FZD7 promotes mesendodermal differentiation of human pluripotent stem cells.eLife · 2020Article
- Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions.Pathology oncology research : POR · 2020Article
- NANOG and LIN28 dramatically improve human cell reprogramming by modulating LIN41 and canonical WNT activities.Biology open · 2019Article
- Mechanisms of Wnt signaling and control.Wiley interdisciplinary reviews. Systems biology and medicine · 2018Review
- ERAD-dependent control of the Wnt secretory factor Evi.The EMBO journal · 2018Article
- The Pleiotropic Effects of the Canonical Wnt Pathway in Early Development and Pluripotency.Genes · 2018Review
- Comparative gene expression study and pathway analysis of the human iris- and the retinal pigment epithelium.PloS one · 2017Article
- hiPSC-derived iMSCs: NextGen MSCs as an advanced therapeutically active cell resource for regenerative medicine.Journal of cellular and molecular medicine · 2016Review
- Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear Accumulation.Stem cell reports · 2016Article
- Anti-cancer drug 3,3'-diindolylmethane activates Wnt4 signaling to enhance gastric cancer cell stemness and tumorigenesis.Oncotarget · 2016Article
- Fatty acylation of Wnt proteins.Nature chemical biology · 2016Article
- Signaling involved in stem cell reprogramming and differentiation.World journal of stem cells · 2015Article
- From "directed differentiation" to "neuronal induction": modeling neuropsychiatric disease.Biomarker insights · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
WNT signaling promotes the reprogramming of somatic cells to an induced pluripotent state. We provide genetic evidence that WNT signaling is a requisite step during the induction of pluripotency. Fibroblasts from individuals with focal dermal hypoplasia (FDH), a rare genetic syndrome caused by mutations in the essential WNT processing enzyme PORCN, fail to reprogram with standard methods. This blockade in reprogramming is overcome by ectopic WNT signaling and PORCN overexpression, thus demonstrating that WNT signaling is essential for reprogramming. The rescue of reprogramming is critically dependent on the level of WNT signaling: steady baseline activation of the WNT pathway yields karyotypically normal iPSCs, whereas daily stimulation with Wnt3a produces FDH-iPSCs with severely abnormal karyotypes. Therefore, although WNT signaling is required for cellular reprogramming, inappropriate activation of WNT signaling induces chromosomal instability, highlighting the precarious nature of ectopic WNT activation and its tight relationship with oncogenic transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.