ArticleJournal of proteomics2015
Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom.
Article in Journal of proteomics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Toxins in disguise: Neuropeptide mimicry across animal venoms.General and comparative endocrinology · 2026Review
- PeptideMiner-neuropeptide discovery across the animal kingdom.GigaScience · 2025Article
- Elucidation of Medusozoan (Jellyfish) Venom Constituent Activities Using Constellation Pharmacology.Toxins · 2024Article
- A phylogeny-aware approach reveals unexpected venom components in divergent lineages of cone snails.Proceedings. Biological sciences · 2021Article
- Combined Proteotranscriptomic-Based Strategy to Discover Novel Antimicrobial Peptides from Cone Snails.Biomedicines · 2021Review
- Hormone-like conopeptides - new tools for pharmaceutical design.RSC medicinal chemistry · 2020Review
- Structural and Functional Characterization of Conotoxins fromMarine drugs · 2020Article
- The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework.The Journal of biological chemistry · 2019Article
- Conopeptides promote itch through human itch receptor hMgprX1.Toxicon : official journal of the International Society on Toxinology · 2018Article
- Venomics-Accelerated Cone Snail Venom Peptide Discovery.International journal of molecular sciences · 2018Review
- New techniques, applications and perspectives in neuropeptide research.The Journal of experimental biology · 2018Review
- Review
- The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.Marine drugs · 2017Article
- Identification of a cono-RFamide from the venom ofProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Hormone-like peptides in the venoms of marine cone snails.General and comparative endocrinology · 2017Article
- In the picture: disulfide-poor conopeptides, a class of pharmacologically interesting compounds.The journal of venomous animals and toxins including tropical diseases · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
In this study, a proteogenomic annotation strategy was used to identify a novel bioactive peptide from the venom of the predatory marine snail Conus victoriae. The peptide, conorfamide-Vc1 (CNF-Vc1), defines a new gene family. The encoded mature peptide was unusual for conotoxins in that it was cysteine-free and, despite low overall sequence similarity, contained two short motifs common to known neuropeptides/hormones. One of these was the C-terminal RF-amide motif, commonly observed in neuropeptides from a range of organisms, including humans. The mature venom peptide was synthesized and characterized structurally and functionally. The peptide was bioactive upon injection into mice, and calcium imaging of mouse dorsal root ganglion (DRG) cells revealed that the peptide elicits an increase in intracellular calcium levels in a subset of DRG neurons. Unusually for most Conus venom peptides, it also elicited an increase in intracellular calcium levels in a subset of non-neuronal cells. BIOLOGICAL SIGNIFICANCE: Our findings illustrate the utility of proteogenomics for the discovery of novel, functionally relevant genes and their products. CNF-Vc1 should be useful for understanding the physiological role of RF-amide peptides in the molluscan and mammalian nervous systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.