ArticleBiology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation2015
Enhanced cytotoxic function of natural killer and CD3+CD56+ cells in cord blood after culture.
Article in Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- HOPX is required for the generation of umbilical cord blood-derived memory-like NK cells induced by three cytokines.Frontiers in immunology · 2026Article
- Manufacturing CAR-NK against tumors: Who is the ideal supplier?Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2024Article
- Improved Antitumor Effect of NK Cells Activated by Neutrophils in a Bone Marrow Transplant Model.Mediators of inflammation · 2023Article
- Chimeric antigen receptor-engineered NK cells: new weapons of cancer immunotherapy with great potential.Experimental hematology & oncology · 2022Review
- Natural adjuvants (Gastroenterology and hepatology from bed to bench · 2022Article
- Review
- NK cells for cancer immunotherapy.Nature reviews. Drug discovery · 2020Review
- Cord-Blood Natural Killer Cell-Based Immunotherapy for Cancer.Frontiers in immunology · 2020Review
- Anti-Relapse effects of donor natural killer cells and IL-2 gene modification on allogeneic hematopoietic stem cell transplantation in acute leukemia.Cancer biomarkers : section A of Disease markers · 2020Article
- A novel immature natural killer cell subpopulation predicts relapse after cord blood transplantation.Blood advances · 2019Article
- Natural killer cells as a therapeutic tool for infectious diseases - current status and future perspectives.Oncotarget · 2018Review
- NK cell therapy after hematopoietic stem cell transplantation: can we improve anti-tumor effect?International journal of hematology · 2018Review
- Development and Selection of the Human Vγ9Vδ2Frontiers in immunology · 2018Review
- Graft-versus-Leukemia Effect Following Hematopoietic Stem Cell Transplantation for Leukemia.Frontiers in immunology · 2017Review
- Cord Blood as a Source of Natural Killer Cells.Frontiers in medicine · 2015Review
- Revving up Natural Killer Cells and Cytokine-Induced Killer Cells Against Hematological Malignancies.Frontiers in immunology · 2015Review
- The Application of Natural Killer Cell Immunotherapy for the Treatment of Cancer.Frontiers in immunology · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rate of immune reconstitution directly correlates with the number of hematopoietic stem cells infused and is particularly delayed in patients undergoing cord blood (CB) transplantation (CBT). Methods to increase the number of CB natural killer (NK) cells have the potential to improve immune reconstitution after CBT. NK cells are the first lymphocyte population to recover after hematopoietic stem cells transplantation and are central to preventing early relapse and infection. CB NK cells are low in number and are known to be incomplete in maturation and require activation for effective function. Here, we report a clinically relevant ex vivo expansion method that increases the number of activated CB NK cells. We report a multilog increase in NK cell number when CB mononuclear cells are cocultured with IL-2 and IL-15. Furthermore, NK cells expressing activating receptors and adhesion molecules responsible for cytotoxicity increased throughout culture, whereas inhibitory receptor expression remained low. Additionally, cytotoxic function against various malignancies was significantly enhanced in cultured NK cells but not CD3(+)CD56(+) cells. These data suggest that ex vivo expansion and activation of CB NK cells is a clinically feasible and relevant approach to prevent early infection and relapse after CBT.
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