ArticleTranslational psychiatry2014
Leptin receptor deficiency confers resistance to behavioral effects of fluoxetine and desipramine via separable substrates.
Article in Translational psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 55 citations in OpenAlex.
- Obese male zucker rats show basilar dendritic retraction in the medial prefrontal cortex.Heliyon · 2024Article
- Effects of the Combination of theBiomolecules · 2023Article
- Interactive Effects of Serum Leptin Levels and Physical Comorbidity on the Pharmacotherapeutic Response of Depressive Disorders.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Article
- Depression with atypical neurovegetative symptoms shares genetic predisposition with immuno-metabolic traits and alcohol consumption.Psychological medicine · 2022Article
- Association Between Self-rating Depression Scores and Total Ghrelin and Adipokine Serum Levels in a Large Population-Based Sample.Frontiers in psychiatry · 2022Article
- High-fat diet induces neuroinflammation and reduces the serotonergic response to escitalopram in the hippocampus of obese rats.Brain, behavior, and immunity · 2021Article
- Systemic TNF-α blockade attenuates anxiety and depressive-like behaviors inSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020Article
- The Way to a Human's Brain Goes Through Their Stomach: Dietary Factors in Major Depressive Disorder.Frontiers in neuroscience · 2020Review
- Impairment of cognitive flexibility in type 2 diabetic db/db mice.Behavioural brain research · 2019Article
- Metformin Promotes Anxiolytic and Antidepressant-Like Responses in Insulin-Resistant Mice by Decreasing Circulating Branched-Chain Amino Acids.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Depression and obesity: evidence of shared biological mechanisms.Molecular psychiatry · 2019Review
- The associations of self-rated health with cardiovascular risk proteins: a proteomics approach.Clinical proteomics · 2019Article
- Hippocampal brain-derived neurotrophic factor determines recruitment of anatomically connected networks after stress in diabetic mice.Hippocampus · 2018Article
- Leptin in depression: a potential therapeutic target.Cell death & disease · 2018Review
- Antidepressant-Like Effects of Acupuncture-Insights From DNA Methylation and Histone Modifications of Brain-Derived Neurotrophic Factor.Frontiers in psychiatry · 2018Article
- Metabolic and Microbiota Measures as Peripheral Biomarkers in Major Depressive Disorder.Frontiers in psychiatry · 2018Review
- Leptin Increases Expression of 5-HTFrontiers in psychiatry · 2018Article
- Genetic Association of Major Depression With Atypical Features and Obesity-Related Immunometabolic Dysregulations.JAMA psychiatry · 2017Article
- Role of the adipose PPARγ-adiponectin axis in susceptibility to stress and depression/anxiety-related behaviors.Molecular psychiatry · 2017Article
- Role of Leptin and Orexin-A Within the Suprachiasmatic Nucleus on Anxiety-Like Behaviors in Hamsters.Molecular neurobiology · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Depression is a complex, heterogeneous mental disorder. Currently available antidepressants are only effective in about one-third to one-half of all patients. The mechanisms underlying antidepressant response and treatment resistance are poorly understood. Recent clinical evidence implicates the involvement of leptin in treatment response to antidepressants. In this study, we determined the functional role of the leptin receptor (LepRb) in behavioral responses to the selective serotonergic antidepressant fluoxetine and the noradrenergic antidepressant desipramine. While acute and chronic treatment with fluoxetine or desipramine in wild-type mice elicited antidepressant-like effects in the forced swim test, mice null for LepRb (db/db) displayed resistance to treatment with either fluoxetine or desipramine. Fluoxetine stimulated phosphorylation of Akt(Thr308) and GSK-3β(Ser9) in the hippocampus and prefrontal cortex (PFC) of wild-type mice but not in db/db mice. Desipramine failed to induce measurable changes in Akt, GSK-3β or ERK1/2 phosphorylation in the hippocampus and PFC, as well as hypothalamus of either genotype of mice. Deletion of LepRb specifically from hippocampal and cortical neurons resulted in fluoxetine insensitivity in the forced swim test and tail suspension test while leaving the response to desipramine intact. These results suggest that functional LepRb is critically involved in regulating the antidepressant-like behavioral effects of both fluoxetine and desipramine. The antidepressant effects of fluoxetine but not desipramine are dependent on the presence of functional LepRb in the hippocampus and cortex.
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Registered trials
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