SynthesisPloS one2014
Are Ureaplasma spp. a cause of nongonococcal urethritis? A systematic review and meta-analysis.
Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- The Associations of Genital Mycoplasmas with Female Infertility and Adverse Pregnancy Outcomes: a Systematic Review and Meta-analysis.Reproductive sciences (Thousand Oaks, Calif.) · 2021Pooled it
- Risk of mycoplasma sepsis after cesarean section: a case-control study.BMC infectious diseases · 2026Article
- Homogeneity Between Cervical and Vaginal Microbiomes and the Diagnostic Limitations of 16S Sequencing for STI Pathogens at Higher Ct Values.International journal of molecular sciences · 2025Article
- Article
- U. Parvum serovars exhibit distinct pathogenicity in Chinese women of childbearing age: a multicentre cross-sectional study.BMC infectious diseases · 2024Article
- Immunocompromised teenager with meningitis caused byBMJ case reports · 2024Article
- Lower Urinary Tract Inflammation and Infection: Key Microbiological and Immunological Aspects.Journal of clinical medicine · 2024Review
- Article
- Sexually transmitted pathogens in asymptomatic women at Rethabile clinic, Limpopo, South Africa.Southern African journal of infectious diseases · 2024Article
- Sexually transmitted coinfections among at-risk HIV-positive MSM: implications for optimal preemptive treatment.Frontiers in medicine · 2024Article
- Prevalence of Mollicutes among men who have sex with men and transgender women aged 15 to 19 years in Salvador, North-eastern Brazil.BMC infectious diseases · 2023Article
- Droplet digital PCR (ddPCR) for the detection and quantification of Ureaplasma spp.BMC infectious diseases · 2021Article
- The Prevalence of Ureaplasma Urealyticum and Mycoplasma Hominis Infections in Infertile Patients in the Northeast Region of Romania.Medicina (Kaunas, Lithuania) · 2021Article
- A novel bioreactor for the stable growth of Ureaplasma parvum and Ureaplasma urealyticum.Journal of microbiological methods · 2021Article
- The effect of screening and treatment of Ureaplasma urealyticum infection on semen parameters in asymptomatic leukocytospermia: a case-control study.BMC urology · 2020Article
- Aetiology and prevalence of mixed-infections and mono-infections in non-gonococcal urethritis in men: a case-control study.Sexually transmitted infections · 2020Article
- The Role ofClinical microbiology reviews · 2019Review
- Classification of non-gonococcal urethritis: a review.International urology and nephrology · 2019Review
- Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient.Transplant infectious disease : an official journal of the Transplantation Society · 2019Article
- Detection of ureaplasmas and bacterial vaginosis associated bacteria and their association with non-gonococcal urethritis in men.PloS one · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNongonococcal urethritis (NGU) is the most common male reproductive tract syndrome. Ureaplasmas spp. including U. urealyticum and U. parvum, have been increasingly reported to be implicated in NGU. However, there are still many contradictions about their pathogenic role in NGU.
aimsThe goals of this study were to evaluate the association of Ureaplasmas spp. with NGU, and to compare the prevalence of Ureaplasmas spp. infection in China relative to the world average.
methodsA systematic review and meta-analysis was conducted following standard guidelines for meta-analysis. The quality of included studies was assessed by Newcastle-Ottawa scale.
resultsA total of seven studies involving 1,507 NGU patients and 1,223 controls were eligible for meta-analysis. There was no significant difference in the Ureaplasma spp. positive rate between the NGU and control groups. However, the U. urealyticum positive rate was significantly higher in NGU patients compared to controls; the U. parvum positive rate was significantly higher in controls compared to NGU patients. Furthermore, within the NGU patient group, the positive rate of U. urealyticum was significantly higher than that of U. parvum, whereas within the control group, the opposite trend was observed. Compared to the world average, a significantly higher positive rate of Ureaplasma spp. was observed in both the NGU and control groups in China.
conclusionsOur analysis supports that U. urealyticum, but not U. parvum, is an etiological agent in NGU. More detailed studies of these two species in China and the world could contribute to a better understanding of the epidemiology and pathogenesis, and facilitate the development of better strategies for treatment and prevention of NGU.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.