Evidence map›Paper›PMID 25463840›Full record

ArticleEarly human development2014

Lifecourse relationship between maternal smoking during pregnancy, birth weight, contemporaneous anthropometric measurements and bone mass at 18years old. The 1993 Pelotas Birth Cohort.

Jeovany Martínez-Mesa, Ana Maria Baptista Menezes, Laura D Howe, Fernando Cesar Wehrmeister, Ludmila Correia Muniz, David Alejandro González-Chica, Maria Cecilia Assunção, Helen Gonçalves, Fernando C Barros

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Early human development, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jeovany Martínez-MesaPostgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. Electronic address: jeovanymm@yahoo.es.
Ana Maria Baptista MenezesPostgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil.
Laura D HoweMRC Integrative Epidemiology Unit at the University of Bristol, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Fernando Cesar WehrmeisterPostgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil.
Ludmila Correia MunizPostgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil.
David Alejandro González-ChicaPostgraduate Program in Nutrition, Federal University of Santa Catarina, Brazil.
Maria Cecilia AssunçãoPostgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil.
Helen GonçalvesPostgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil.
Fernando C BarrosPost-graduate Program in Health and Behavior, Catholic University of Pelotas, Rio Grande do Sul, Brazil.
Universidade Federal de Pelotas · BRUniversidade Católica de Pelotas · BRUniversidade Federal de Santa Catarina · BRUniversity of Bristol · GB

Funding

Medical Research Council G1002375Wellcome TrustWellcome Trust G086974/Z/08/Z
6 · The paper itself

Abstract

backgroundMaternal smoking during pregnancy is associated with short-term and also long-term harmful effects on offspring.

objectiveThe aim of this study is to evaluate the associations of maternal smoking during pregnancy with offspring bone health at 18years old, and the role of birth weight and contemporaneous height, weight and body mass index (BMI) in this association. Data from the 1993 Pelotas Birth Cohort were analyzed using path analysis stratified by sex. Adolescents at 18 years old (N=1512 males, 1563 females). DXA-determined total body bone mineral density (BMD) and bone mineral content (BMC) were assessed at 18 years old.

resultsEach additional cigarette smoked during pregnancy was associated with a lower BMC by -4.20 g in males (95% CI -8.37; -0.05), but not in females [-2.22 g (95% CI -5.49; 1.04)]; weaker inverse associations were observed for BMD. This inverse association was explained by the influence of maternal smoking on birth weight and contemporaneous anthropometry, particularly height. A 1 kg higher birth weight was associated with a higher BMC by around 144 g in males and by around 186 g in females, and also with a higher BMD by around 0.019 g/cm(2) in males and by around 0.018 g/cm(2) in females, respectively.

conclusionsLifecourse analysis using path models has enabled to evaluate the role of mediators in the associations of maternal smoking during pregnancy and birth weight with bone mass in the offspring, thus generating improved understanding of the etiology of bone health and the importance of early life experiences.

Indexed as

Birth WeightBody HeightBody Mass IndexBone DensityPrenatal Exposure Delayed EffectsAdolescentCohort StudiesFemaleHumansMalePregnancySmokingAbsorptiometryBirth weightBody mass indexBone contentBone densityBone massHeightLongitudinal studiesPath analysisPhotonSmokingStructural equation model

Identifiers

PMID25463840
PMCPMC4252063
OpenAlexW2073263942

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.