SynthesisBrain and language2014
Stuttering, induced fluency, and natural fluency: a hierarchical series of activation likelihood estimation meta-analyses.
Synthesis in Brain and language, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Frontal Aslant Tract: A Systematic Review for Neurosurgical Applications.Frontiers in neurology · 2021Pooled it
- Trial
- Transcranial direct current stimulation over left inferior frontal cortex improves speech fluency in adults who stutter.Brain : a journal of neurology · 2018Trial
- Investigating the feasibility of using transcranial direct current stimulation to enhance fluency in people who stutter.Brain and language · 2017Trial
- Unraveling the mystery of stuttering: clinical and physiological insights into its manifestation.Frontiers in human neuroscience · 2026Article
- Cortical somatosensory responses evoked by orofacial skin stretch experimentally applied during speech movement planning in stuttering and nonstuttering adults.IBRO neuroscience reports · 2025Article
- Nonverbal Communication Processing in Deaf Adults: An Activation Likelihood Estimation Meta-Analysis.Brain sciences · 2025Review
- The Effects of tDCS on Speech Fluency in People Who Stutter: A Narrative Review.The European journal of neuroscience · 2025Review
- Contemporary clinical conversations about stuttering: What does brain imaging research mean to clinicians?International journal of speech-language pathology · 2025Article
- An fMRI study of initiation and inhibition of manual and spoken responses in people who stutter.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Delayed auditory feedback increases speech production variability in typically fluent adults but has the opposite effect in stuttering adults.Frontiers in human neuroscience · 2025Article
- Knowns and unknowns about the neurobiology of stuttering.PLoS biology · 2024Article
- Reactive Inhibitory Control Precedes Overt Stuttering Events.Neurobiology of language (Cambridge, Mass.) · 2024Article
- Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?Frontiers in human neuroscience · 2024Article
- Therapeutic potential of robots for people who stutter: a preliminary study.Frontiers in psychiatry · 2024Article
- A comparison of structural morphometry in children and adults with persistent developmental stuttering.Brain communications · 2023Article
- Brain activity during the preparation and production of spontaneous speech in children with persistent stuttering.NeuroImage. Clinical · 2023Article
- Effect of an Auditory Temporal Training Program on Speech Fluency of Children with Developmental Stuttering.Iranian journal of child neurology · 2023Article
- Tract profiles of the cerebellar peduncles in children who stutter.Brain structure & function · 2022Article
- Structural brain network topological alterations in stuttering adults.Brain communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Developmental stuttering is a speech disorder most likely due to a heritable form of developmental dysmyelination impairing the function of the speech-motor system. Speech-induced brain-activation patterns in persons who stutter (PWS) are anomalous in various ways; the consistency of these aberrant patterns is a matter of ongoing debate. Here, we present a hierarchical series of coordinate-based meta-analyses addressing this issue. Two tiers of meta-analyses were performed on a 17-paper dataset (202 PWS; 167 fluent controls). Four large-scale (top-tier) meta-analyses were performed, two for each subject group (PWS and controls). These analyses robustly confirmed the regional effects previously postulated as "neural signatures of stuttering" (Brown, Ingham, Ingham, Laird, & Fox, 2005) and extended this designation to additional regions. Two smaller-scale (lower-tier) meta-analyses refined the interpretation of the large-scale analyses: (1) a between-group contrast targeting differences between PWS and controls (stuttering trait); and (2) a within-group contrast (PWS only) of stuttering with induced fluency (stuttering state).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.