Evidence map›Paper›PMID 25463613›Full record

ArticleVirology2015

Evolutionary genetics and vector adaptation of recombinant viruses of the western equine encephalitis antigenic complex provides new insights into alphavirus diversity and host switching.

Andrew B Allison, David E Stallknecht, Edward C Holmes

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

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  17. Evolutionary ecology of virus emergence.Annals of the New York Academy of Sciences · 2017
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Andrew B AllisonBaker Institute for Animal Health, Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA; Southeastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. Electronic address: aba75@cornell.edu.
David E StallknechtSoutheastern Cooperative Wildlife Disease Study, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Edward C HolmesMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Biological Sciences and Sydney Medical School, University of Sydney, New South Wales 2006, Australia.
University of Georgia · USThe University of Sydney · AU

Funding

Host cell receptor variation and control of viral cross-species transmissionF32AI100545 · NIAID · CORNELL UNIVERSITY · PI ALLISON, ANDREW BROWNELL · 2013 to 2015
$165k
NIAID NIH HHS F32 AI100545NIAID NIH HHS F32AI100545
6 · The paper itself

Abstract

Western equine encephalitis virus (WEEV), Highlands J virus (HJV), and Fort Morgan virus (FMV) are the sole representatives of the WEE antigenic complex of the genus Alphavirus, family Togaviridae, that are endemic to North America. All three viruses have their ancestry in a recombination event involving eastern equine encephalitis virus (EEEV) and a Sindbis (SIN)-like virus that gave rise to a chimeric alphavirus that subsequently diversified into the present-day WEEV, HJV, and FMV. Here, we present a comparative analysis of the genetic, ecological, and evolutionary relationships among these recombinant-origin viruses, including the description of a nsP4 polymerase mutation in FMV that allows it to circumvent the host range barrier to Asian tiger mosquito cells, a vector species that is normally refractory to infection. Notably, we also provide evidence that the recombination event that gave rise to these three WEEV antigenic complex viruses may have occurred in North America.

Indexed as

AlphavirusAmino Acid SequenceAnimalsAntigens, ViralBase SequenceCulicidaeEncephalitis Virus, Western EquineEncephalomyelitis, Western EquineEvolution, MolecularGenetic VariationHorse DiseasesHorsesHost SpecificityInsect VectorsMolecular Sequence DataMutationAntigens, ViralRNA, ViralAlphavirusFort Morgan virusHighlands J virusHost rangeRecombinationTogavirusVirus emergenceWestern equine encephalitis antigenic complexWestern equine encephalitis virus

Identifiers

PMID25463613
PMCPMC4259830
OpenAlexW2048635955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.