ArticleActa biomaterialia2015
A mild process to design silk scaffolds with reduced β-sheet structure and various topographies at the nanometer scale.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 62 citations in OpenAlex.
- Development of Small-Diameter Silk Vascular Grafts Supported by Solid-State Nuclear Magnetic Resonance Structural Analysis.Molecules (Basel, Switzerland) · 2025Review
- Development of Silk Fibroin-Based Non-Crosslinking Thermosensitive Bioinks for 3D Bioprinting.Polymers · 2023Article
- Effect of pH on the Conformational Transition of Silk Fibroin in Aqueous Solution Monitored by Thioflavin-T Fluorescence.Journal of fluorescence · 2022Article
- Injectable hydrogel systems with multiple biophysical and biochemical cues for bone regeneration.Biomaterials science · 2020Article
- Fabrication of Silk-Hyaluronan Composite as a Potential Scaffold for Tissue Repair.Frontiers in bioengineering and biotechnology · 2020Article
- Growth factor-free salt-leached silk scaffolds for differentiating endothelial cells.Journal of materials chemistry. B · 2018Article
- Silk fibroin scaffolds with inverse opal structure for bone tissue engineering.Journal of biomedical materials research. Part B, Applied biomaterials · 2017Article
- Simulation of ECM with Silk and Chitosan Nanocomposite Materials.Journal of materials chemistry. B · 2017Article
- Shape Memory Silk Protein Sponges for Minimally Invasive Tissue Regeneration.Advanced healthcare materials · 2017Article
- Glycerin-Induced Conformational Changes in Bombyx mori Silk Fibroin Film Monitored by (13)C CP/MAS NMR and ¹H DQMAS NMR.International journal of molecular sciences · 2016Article
- Silk Biomaterials with Vascularization Capacity.Advanced functional materials · 2016Article
- Repair, protection and regeneration of peripheral nerve injury.Neural regeneration research · 2015Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Three-dimensional (3-D) porous silk scaffolds with good biocompatibility and minimal immunogenicity show promise in a range of tissue regeneration applications. However, the challenge remains to effectively fabricate their microstructures and mechanical properties to satisfy the specific requirements of different tissues. In this study, silk scaffolds were fabricated to form an extracellular matrix (ECM) mimetic nanofibrous architecture using a mild process. A slowly increasing concentration process was applied to regulate silk self-assembly into nanofibers in aqueous solution. Then glycerol was blended with the nanofiber solution and induced silk crystallization in the lyophilization process, endowing freeze-dried scaffolds with water stability. The glycerol was leached from the scaffolds, leaving a similar porous structure at the micrometer scale but different topographies at the nanoscale. Compared to previous salt-leached and methanol-annealed scaffolds, the present scaffolds showed lower β-sheet content, softer mechanical property and improved cell growth and differentiation behaviors, suggesting their promising future as platforms for controlling stem cell fate and soft tissue regeneration.
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