ArticleOsteoarthritis and cartilage2015
Surgical induction, histological evaluation, and MRI identification of cartilage necrosis in the distal femur in goats to model early lesions of osteochondrosis.
Article in Osteoarthritis and cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Management and Outcomes of Osteochondritis Dissecans of the Knee in the Pediatric and Adolescent Population.Current reviews in musculoskeletal medicine · 2026Review
- Anaesthesia for pigs, sheep, goats and cattle involved in biomedical research: FELASA working group guidelines-Parts I-IV.Laboratory animals · 2026Article
- Longitudinal In Vivo 3T MRI of Naturally Occurring Early Osteochondrosis Lesions in the Piglet Humeral Epiphyseal Cartilage and Growth Plate.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Juvenile Osteochondritis Dissecans: A Case Report.Diagnostics (Basel, Switzerland) · 2024Article
- Epiphyseal cartilage vascular architecture at the distal humeral osteochondritis dissecans predilection site in juvenile pigs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2024Article
- Relationship between the extent of vascular injury and the evolution of surgically induced osteochondrosis lesions in a piglet model.PloS one · 2024Article
- Refixation of a Large Osteochondral Fragment with Magnesium Compression Screws-A Case Report.Life (Basel, Switzerland) · 2023Article
- Vascularity of the early post-natal human distal femoral chondroepiphysis: Quantitative MRI analysis.Journal of children's orthopaedics · 2022Article
- T1ρ and T2 mapping detect acute ischemic injury in a piglet model of Legg-Calvé-Perthes disease.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Evaluation of the Suitability of Miniature Pigs as an Animal Model of Juvenile Osteochondritis Dissecans.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Article
- Identification of Areas of Epiphyseal Cartilage Necrosis at Predilection Sites of Juvenile Osteochondritis Dissecans in Pediatric Cadavers.The Journal of bone and joint surgery. American volume · 2018Article
- Quantitative MRI Helps to Detect Hip Ischemia: Preclinical Model of Legg-Calvé-Perthes Disease.Radiology · 2018Article
- Non-linear optical microscopy of cartilage canals in the distal femur of young pigs may reveal the cause of articular osteochondrosis.BMC veterinary research · 2017Article
- In vivo visualization using MRI TJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017Article
- Quantitative susceptibility mapping detects abnormalities in cartilage canals in a goat model of preclinical osteochondritis dissecans.Magnetic resonance in medicine · 2017Article
- Multi-parametric MRI characterization of enzymatically degraded articular cartilage.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Capturing fast relaxing spins with SWIFT adiabatic rotating frame spin-lattice relaxation (T1ρ) mapping.NMR in biomedicine · 2016Article
- Novel Application of Magnetic Resonance Imaging Demonstrates Characteristic Differences in Vasculature at Predilection Sites of Osteochondritis Dissecans.The American journal of sports medicine · 2015Article
- Multiparametric MRI of Epiphyseal Cartilage Necrosis (Osteochondrosis) with Histological Validation in a Goat Model.PloS one · 2015Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveIdentify and interrupt the vascular supply to portions of the distal femoral articular-epiphyseal cartilage complex (AECC) in goat kids to induce cartilage necrosis, characteristic of early lesions of osteochondrosis (OC); then utilize magnetic resonance imaging (MRI) to identify necrotic areas of cartilage.
designDistal femora were perfused and cleared in goat kids of various ages to visualize the vascular supply to the distal femoral AECC. Vessels located on the axial aspect of the medial femoral condyle (MFC) and on the abaxial side of the lateral trochlear ridge were transected in eight 4- to 5-day-old goats to induce cartilage necrosis. Goats were euthanized 1, 2, 3, 4, 5, 6, 9, and 10 weeks post operatively and operated stifles were harvested. Adiabatic T1ρ relaxation time maps of the harvested distal femora were generated using a 9.4 T MR scanner, after which samples were evaluated histologically.
resultsInterruption of the vascular supply to the MFC caused lesions of cartilage necrosis in 6/8 goat kids that were demonstrated histologically. Adiabatic T1ρ relaxation time mapping identified these areas of cartilage necrosis in 5/6 cases. No significant findings were detected after transection of perichondrial vessels supplying the lateral trochlear ridge.
conclusionsCartilage necrosis, characteristic of early OC, can be induced by interrupting the vascular supply to the distal femoral AECC in goat kids. The ability of high field MRI to identify these areas of cartilage necrosis in the AECC using the adiabatic T1ρ sequence suggests that this technique may be useful in the future for the early diagnosis of OC.
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