ArticleNature communications2014
Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 1 of them a synthesis that pooled it.
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Who cites it
88 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.
- Trained innate immunity.Immunologic research · 2021Pooled it
- Turning Red to Green Repeatedly: Ancestral LWS Duplications Drive Convergent Visual Tuning in Teleost Fishes.Molecular ecology · 2026Article
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- Opsin gene evolution in aquatic, amphibious and terrestrial blennies (Blenniidae).Biology open · 2026Article
- Shared and Divergent Transcriptional Programs of Oligodendrocyte Differentiation Across Vertebrate Species Revealed by scRNA-seq Analysis.International journal of molecular sciences · 2026Article
- Transition From Land to Sea: Comparative Genomics Illuminates the Adaptive Evolution of the Intertidal Spider.Molecular ecology resources · 2026Article
- PecbloodinApplied and environmental microbiology · 2026Article
- Insight into the Evolution of Mitochondrial Genetic Basis of Amphibious Adaptation in the Goby (Teleostei: Gobiidae).Journal of molecular evolution · 2026Review
- Chromosome-Level Genome Assembly of the Loach Goby Rhyacichthys aspro Offers Insights Into Gobioidei Evolution.Molecular ecology resources · 2025Article
- Chromosome-level genome assembly of Cheilinus chlorourus (Bloch, 1791) (Perciformes: Labridae).Scientific data · 2025Article
- Chromosome-level genome assembly reveals adaptive evolution of the invasive Amazon sailfin catfish (Pterygoplichthys pardalis).Communications biology · 2025Article
- Klumpy: A tool to evaluate the integrity of long-read genome assemblies and illusive sequence motifs.Molecular ecology resources · 2025Article
- The whole chromosome-level genome provides resources and insights into the endangered fish Percocypris pingi evolution and conservation.BMC genomics · 2024Article
- Advances in biotechnology and breeding innovations in China's marine aquaculture.Advanced biotechnology · 2024Review
- Genomic landscape of introgression from the ghost lineage in a gobiid fish uncovers the generality of forces shaping hybrid genomes.Molecular ecology · 2024Article
- Decoding the fish genome opens a new era in important trait research and molecular breeding in China.Science China. Life sciences · 2024Review
- Anatomical insights into fish terrestrial locomotion: A study of barred mudskipper (Periophthalmus argentilineatus) fins based on μCT 3D reconstructions.Journal of anatomy · 2024Article
- Chromosome-level genome assembly of the glass catfish (Zoological research · 2024Article
- Expansion and Functional Diversification of Long-Wavelength-Sensitive Opsin in Anabantoid Fishes.Journal of molecular evolution · 2024Article
- Genomic insights into the seawater adaptation in Cyprinidae.BMC biology · 2024Article
28 more citing papers are in PubMed but not listed here.
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Authors and funding
44 authors at 7 institutions in 5 countries.
Funding
Abstract
Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers' tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.