ReviewFree radical biology & medicine2015
Alternative functions of the brain transsulfuration pathway represent an underappreciated aspect of brain redox biochemistry with significant potential for therapeutic engagement.
Review in Free radical biology & medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Experimental upregulation of Lancl1 promotes axon regeneration after optic nerve injury in vivo.Experimental neurology · 2026Article
- IDH-mutant inhibitors enhance the sensitivity of IDH1-mutant gliomas to cysteine-methionine deprivation and ferroptosis.bioRxiv : the preprint server for biology · 2026Article
- CTB-targeted protocells enhance ability of lanthionine ketenamine analogs to induce autophagy in motor neuron-like cells.Scientific reports · 2023Article
- Homocysteinylation and Sulfhydration in Diseases.Current neuropharmacology · 2022Review
- Effects of Lanthionine Ketimine-5-Ethyl Ester on the α-Synucleinopathy Mouse Model.Neurochemical research · 2022Article
- An overview of sulfur-containing compounds originating from natural metabolites: Lanthionine ketimine and its analogues.Analytical biochemistry · 2020Review
- Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance.British journal of cancer · 2020Article
- Chemistry and Biochemistry of Sulfur Natural Compounds: Key Intermediates of Metabolism and Redox Biology.Oxidative medicine and cellular longevity · 2020Review
- NSC-34 motor neuron-like cells are sensitized to ferroptosis upon differentiation.FEBS open bio · 2019Article
- Targeted metabolomic profiling of low and high grade serous epithelial ovarian cancer tissues: a pilot study.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- Review
- Role for Cystathionine γ Lyase (CSE) in an Ethanol (E)-Induced Lesion in Fetal Brain GSH Homeostasis.International journal of molecular sciences · 2018Article
- Total sulfane sulfur bioavailability reflects ethnic and gender disparities in cardiovascular disease.Redox biology · 2018Article
- Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death.Physiology (Bethesda, Md.) · 2018Review
- Multiple-step, one-pot synthesis of 2-substituted-3-phosphono-1-thia-4-aza-2-cyclohexene-5-carboxylates and their corresponding ethyl esters.Bioorganic & medicinal chemistry letters · 2018Article
- Redox-based therapeutics in neurodegenerative disease.British journal of pharmacology · 2017Review
- The Enzymology of 2-Hydroxyglutarate, 2-Hydroxyglutaramate and 2-Hydroxysuccinamate and Their Relationship to Oncometabolites.Biology · 2017Article
- LanCL proteins are not Involved in Lanthionine Synthesis in Mammals.Scientific reports · 2017Article
- Reciprocal Control of Thyroid Binding and the Pipecolate Pathway in the Brain.Neurochemical research · 2017Review
- G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Scientific appreciation for the subtlety of brain sulfur chemistry has lagged, despite understanding that the brain must maintain high glutathione (GSH) to protect against oxidative stress in tissue that has both a high rate of oxidative respiration and a high content of oxidation-prone polyunsaturated fatty acids. In fact, the brain was long thought to lack a complete transsulfuration pathway (TSP) for cysteine synthesis. It is now clear that not only does the brain possess a functional TSP, but brain TSP enzymes catalyze a rich array of alternative reactions that generate novel species including the gasotransmitter hydrogen sulfide (H2S) and the atypical amino acid lanthionine (Lan). Moreover, TSP intermediates can be converted to unusual cyclic ketimines via transamination. Cell-penetrating derivatives of one such compound, lanthionine ketimine (LK), have potent antioxidant, neuroprotective, neurotrophic, and antineuroinflammatory actions and mitigate diverse neurodegenerative conditions in preclinical rodent models. This review will explore the source and function of alternative TSP products, and lanthionine-derived metabolites in particular. The known biological origins of lanthionine and its ketimine metabolite will be described in detail and placed in context with recent discoveries of a GSH- and LK-binding brain protein called LanCL1 that is proving essential for neuronal antioxidant defense; and a related LanCL2 homolog now implicated in immune sensing and cell fate determinations. The review will explore possible endogenous functions of lanthionine metabolites and will discuss the therapeutic potential of lanthionine ketimine derivatives for mitigating diverse neurological conditions including Alzheimer׳s disease, stroke, motor neuron disease, and glioma.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.