ArticleAtherosclerosis2014
Small high-density lipoprotein is associated with monocyte subsets in stable coronary artery disease.
Article in Atherosclerosis, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The association between paraoxonase 1 activity and the susceptibilities of diabetes mellitus, diabetic macroangiopathy and diabetic microangiopathy.Journal of cellular and molecular medicine · 2018Pooled it
- Proprotein convertase subtilisin/kexin type 9-CC-motif chemokine ligand 2 interactions link lipoprotein(a) composition to intermediate monocyte inflammation in coronary artery disease.Atherosclerosis plus · 2026Article
- The sentinels of coronary artery disease: heterogeneous monocytes.Frontiers in immunology · 2025Review
- Investigating Causal Links between Metabolite Profiles and Ulcerative Colitis: A Bidirectional Mendelian Randomization Study.Journal of medical signals and sensors · 2025Article
- PALM: a powerful and adaptive latent model for prioritizing risk variants with functional annotations.Bioinformatics (Oxford, England) · 2023Article
- Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation.Clinical epigenetics · 2022Article
- Nature versus Number: Monocytes in Cardiovascular Disease.International journal of molecular sciences · 2021Review
- The Association of Lipoprotein(a) and Circulating Monocyte Subsets with Severe Coronary Atherosclerosis.Journal of cardiovascular development and disease · 2021Article
- Lower HDL-C levels are associated with higher expressions of CD16 on monocyte subsets in coronary atherosclerosis.International journal of medical sciences · 2020Observational
- Monocyte Subsets, Stanford-A Acute Aortic Dissection, and Carotid Artery Stenosis: New Evidences.Journal of immunology research · 2019Observational
- High-Density Lipoprotein Reduction Differentially Modulates to Classical and Nonclassical Monocyte Subpopulations in Metabolic Syndrome Patients and in LPS-Stimulated Primary Human MonocytesJournal of immunology research · 2018Article
- Article
- Relapsing-remitting multiple sclerosis patients display an altered lipoprotein profile with dysfunctional HDL.Scientific reports · 2017Article
- The relationship between non-HDL cholesterol and macrophage phenotypes in human adipose tissue.Journal of lipid research · 2016Article
- Differential in vivo activation of monocyte subsets during low-grade inflammation through experimental endotoxemia in humans.Scientific reports · 2016Article
- Effect of short term aerobic exercise on fasting and postprandial lipoprotein subfractions in healthy sedentary men.Lipids in health and disease · 2015Article
- Nonclassical patrolling monocyte function in the vasculature.Arteriosclerosis, thrombosis, and vascular biology · 2015Review
- Analysis of high risk factors and characteristics of coronary artery in premenopausal women with coronary artery disease.International journal of clinical and experimental medicine · 2015Article
- Changes of monocyte subsets in patients with acute coronary syndrome and correlation with myocardial injury markers.International journal of clinical and experimental pathology · 2015Article
- Monocyte subset distribution in patients with stable atherosclerosis and elevated levels of lipoprotein(a).Journal of clinical lipidologyArticle
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHigh-density lipoprotein (HDL) particles are heterogeneous in structure and function and the role of HDL subfractions in atherogenesis is not well understood. It has been suggested that small HDL may be dysfunctional in patients with coronary artery disease (CAD). Monocytes are considered to play a key role in atherosclerotic diseases. Circulating monocytes can be divided into three subtypes according to their surface expression of CD14 and CD16. Our aim was to examine whether monocyte subsets are associated with HDL subfractions in patients with atherosclerosis.
methodsWe included 90 patients with angiographically stable CAD. Monocyte subsets were defined as classical monocytes (CD14++CD16-; CM), intermediate monocytes (CD14++CD16+; IM) and non-classical monocytes (CD14+CD16++; NCM). HDL subfractions were measured by electrophoresis on polyacrylamide gel.
resultsSerum levels of small HDL correlated with circulating pro-inflammatory NCM and showed an inverse relationship to circulating CM independently from other lipid parameters, risk factors, inflammatory parameters or statin treatment regime, respectively. IM were not associated with small HDL. In particular, patients with small HDL levels in the highest tertile showed dramatically increased levels of NCM (14.7 ± 7% vs. 10.7 ± 5% and 10.8 ± 5%; p = 0.006) and a decreased proportion of CM (79.3 ± 7% vs. 83.7 ± 6% and 83.9 ± 6%; p = 0.004) compared to patients in the two lower tertiles. In contrast, intermediate HDL, large HDL and total HDL were not associated with monocyte subset distribution.
conclusionSmall HDL levels are associated with pro-inflammatory NCM and inversely correlated with CM. This may suggest that small HDL could have dysfunctional anti-inflammatory properties in patients with established CAD.
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Registered trials
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