Evidence map›Paper›PMID 25462898›Full record

Trial reportPsychoneuroendocrinology2015

Vasopressin, but not oxytocin, increases empathic concern among individuals who received higher levels of paternal warmth: A randomized controlled trial.

Benjamin A Tabak, Meghan L Meyer, Elizabeth Castle, Janine M Dutcher, Michael R Irwin, Jung H Han, Matthew D Lieberman, Naomi I Eisenberger

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psychoneuroendocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01680718 (Neuropeptides and Social Behavior), which is not on this map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
7.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01680718 early_phase1completednot on this map

Neuropeptides and Social Behavior

TypeinterventionalSponsorUniversity of California, Los AngelesRan2012 to 2013Enrolled160ConditionsSocial PsychologyArmsIntranasal oxytocin, Intranasal vasopressin, Intranasal placebo
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Prenatal stress and enhanced developmental plasticity.Journal of neural transmission (Vienna, Austria : 1996) · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Benjamin A TabakDepartment of Psychology, University of California - Los Angeles, CA, United States. Electronic address: btabak@psych.ucla.edu.
Meghan L MeyerDepartment of Psychology, University of California - Los Angeles, CA, United States.
Elizabeth CastleDepartment of Psychology, University of California - Los Angeles, CA, United States.
Janine M DutcherDepartment of Psychology, University of California - Los Angeles, CA, United States.
Michael R IrwinDepartment of Psychology, University of California - Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California - Los Angeles, CA, United States; Cousins Center for Psychoneuroimmunology, David Geffen School of Medicine, University of California - Los Angeles, CA, United States; Semel Institute for Neuroscience, David Geffen School of Medicine, University of California - Los Angeles, CA, United States.
Jung H HanDepartment of Psychology, University of California - Los Angeles, CA, United States.
Matthew D LiebermanDepartment of Psychology, University of California - Los Angeles, CA, United States; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California - Los Angeles, CA, United States.
Naomi I EisenbergerDepartment of Psychology, University of California - Los Angeles, CA, United States.
University of California, Los Angeles · USNeurobehavioral Systems · US

Funding

PREVENTION RESEARCH TRAINING:URBAN CHILDREN'S MENT HLTHT32MH015750 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHRISTINE DUNKEL SCHETTER · 1985 to 2026
$6.2M
NIMH NIH HHS T32 MH015750NIMH NIH HHS T32MH015750
6 · The paper itself

Abstract

backgroundEmpathy improves our ability to communicate in social interactions and motivates prosocial behavior. The neuropeptides arginine vasopressin and oxytocin play key roles in socioemotional processes such as pair bonding and parental care, which suggests that they may be involved in empathic processing.

methodsWe investigated how vasopressin and oxytocin affect empathic responding in a randomized, double-blind, placebo controlled, between-subjects study design. We also examined the moderating role of parental warmth, as reported in the early family environment, on empathic responding following vasopressin, oxytocin, or placebo administration.

resultsAmong participants who reported higher levels of paternal warmth (but not maternal warmth), vasopressin (vs. placebo and oxytocin) increased ratings of empathic concern after viewing distressing and uplifting videos. No main or interaction effects were found for individuals who received oxytocin.

conclusionsVasopressin has a role in enhancing empathy among individuals who received higher levels of paternal warmth.

trial registrationNCT01680718.

Indexed as

Father-Child RelationsSocial BehaviorAdolescentAdultDouble-Blind MethodEmpathyFemaleHumansMaleOxytocinVasopressinsYoung AdultOxytocinVasopressinsEmpathic concernIntranasal administrationOxytocinPaternal warmthVasopressin

Identifiers

PMID25462898
PMCPMC4268337
OpenAlexW1987742093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.