ArticleActa biomaterialia2015
Supramolecular assembly of multifunctional maspin-mimetic nanostructures as a potent peptide-based angiogenesis inhibitor.
Article in Acta biomaterialia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cancer Therapy with Polymeric Nanocarriers and the Transition to Targeted Cancer Therapy: Advances and Future Directions.Pharmaceutical nanotechnology · 2026Review
- Inhibitory effect of maspinon neovascularization in diabetic retinopathy.World journal of diabetes · 2021Article
- (Macro)molecular self-assembly for hydrogel drug delivery.Advanced drug delivery reviews · 2021Review
- Dual-ligand supramolecular nanofibers inspired by the renin-angiotensin system for the targeting and synergistic therapy of myocardial infarction.Theranostics · 2021Article
- Biomimetic peptide self-assembly for functional materials.Nature reviews. Chemistry · 2020Article
- Nanotechnology for angiogenesis: opportunities and challenges.Chemical Society reviews · 2020Review
- Self-assembling peptide-based building blocks in medical applications.Advanced drug delivery reviews · 2017Review
- Supramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility.Nano letters · 2016Article
- Biopolymers and supramolecular polymers as biomaterials for biomedical applications.MRS bulletin · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Aberrant angiogenesis plays a large role in pathologies ranging from tumor growth to macular degeneration. Anti-angiogenic proteins have thus come under scrutiny as versatile, potent therapeutics but face problems with purification and tissue retention. We report here on the synthesis of supramolecular nanostructures that mimic the anti-angiogenic activity of maspin, a class II tumor suppressor protein. These maspin-mimetic nanostructures are formed via self-assembly of small peptide amphiphiles containing the g-helix motif of maspin. Using tubulogenesis assays with human umbilical vein endothelial cells, we demonstrate that maspin-mimetic nanostructures show anti-angiogenic activity at concentrations that are significantly lower than those necessary for the g-helix peptide. Furthermore, in vivo assays in the chick chorioallantoic membrane show maspin-mimetic nanostructures to be effective over controls at inhibiting angiogenesis. Thus, the nanostructures investigated here offer an attractive alternative to the use of anti-angiogenic recombinant proteins in the treatment of cancer or other diseases involving abnormal blood vessel formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.