Evidence map›Paper›PMID 25462787›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2015

Segregated responses of mammary gland development and vaginal opening to prepubertal genistein exposure in Bscl2(-/-) female mice with lipodystrophy.

Rong Li, Ahmed E El Zowalaty, Weiqin Chen, Elizabeth A Dudley, Xiaoqin Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rong LiDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. Electronic address: lirong9@uga.edu.
Ahmed E El ZowalatyDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. Electronic address: ahmdezat@uga.edu.
Weiqin ChenDepartment of Physiology, Georgia Regents University, Augusta, GA 30912, USA. Electronic address: wechen@gru.edu.
Elizabeth A DudleyDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. Electronic address: ldudley9@uga.edu.
Xiaoqin YeDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA; Interdisciplinary Toxicology Program, University of Georgia, Athens, GA 30602, USA. Electronic address: ye@uga.edu.
University of Georgia · USGeorgia Regents Medical Center · US

Funding

Molecular mechanism of LPA3-mediated uterine receptivityR01HD065939 · NICHD · UNIVERSITY OF GEORGIA · PI YE, XIAOQIN · 2011 to 2015
$1.5M
Luminal epithelial microenvironment in Lpar3(-/-) peri-implantation uterusR15HD066301 · NICHD · UNIVERSITY OF GEORGIA · PI YE, XIAOQIN · 2010 to 2010
$371k
NICHD NIH HHS R01 HD065939NICHD NIH HHS R01HD065939NICHD NIH HHS R15 HD066301NICHD NIH HHS R15HD066301
6 · The paper itself

Abstract

Berardinelli-Seip congenital lipodystrophy 2-deficient (Bscl2(-/-)) mice recapitulate human BSCL2 disease with lipodystrophy. Bscl2-encoded seipin is detected in adipocytes and epithelium of mammary gland. Postnatal mammary gland growth spurt and vaginal opening signify pubertal onset in female mice. Bscl2(-/-) females have longer and dilated mammary gland ducts at 5-week old and delayed vaginal opening. Prepubertal exposure to 500ppm genistein diet increases mammary gland area and accelerates vaginal opening in both control and Bscl2(-/-) females. However, genistein treatment increases ductal length in control but not Bscl2(-/-) females. Neither prepubertal genistein treatment nor Bscl2-deficiency affects phospho-estrogen receptor α or progesterone receptor expression patterns in 5-week old mammary gland. Interestingly, Bscl2-deficiency specifically reduces estrogen receptor β expression in mammary gland ductal epithelium. In summary, Bscl2(-/-) females have accelerated postnatal mammary ductal development but delayed vaginal opening; they display segregated responses in mammary gland development and vaginal opening to prepubertal genistein treatment.

Indexed as

Age FactorsAnimalsDisease Models, AnimalEstrogen Receptor alphaEstrogen Receptor betaFemaleGenisteinGTP-Binding Protein gamma SubunitsHeterotrimeric GTP-Binding ProteinsLipodystrophy, Congenital GeneralizedMammary Glands, AnimalMice, Inbred C57BLMice, KnockoutPhosphorylationReceptors, ProgesteroneSexual DevelopmentBscl2 protein, mouseEstrogen Receptor alphaEstrogen Receptor betaGenisteinGTP-Binding Protein gamma SubunitsHeterotrimeric GTP-Binding ProteinsReceptors, ProgesteroneBscl2/SeipinGenisteinLipodystrophyMammary glandPubertyVaginal opening

Identifiers

PMID25462787
PMCPMC4420718
OpenAlexW1964275358

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.