ArticleReproductive toxicology (Elmsford, N.Y.)2015
Identification of environmental chemicals that induce yolk malabsorption in zebrafish using automated image segmentation.
Article in Reproductive toxicology (Elmsford, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- Developmental Toxicity of Photolithography-Relevant Per- and Polyfluoroalkyl Substances (PFAS) Reveals Concerns for Less-Studied Functional Groups.Environmental science & technology · 2026Article
- Temperature-dependence of early development of zebrafish and the consequences for laboratory use and animal welfare.PloS one · 2025Article
- The herbicide acetochlor causes lipid peroxidation by inhibition of glutathione peroxidase activity.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Advanced Techniques for the Intelligent Diagnosis of Fish Diseases: A Review.Animals : an open access journal from MDPI · 2022Review
- Mathematical modeling of the interaction between yolk utilization and fish growth in zebrafish, Danio rerio.Development (Cambridge, England) · 2021Article
- Zebrafish as a Model for Toxicological Perturbation of Yolk and Nutrition in the Early Embryo.Current environmental health reports · 2018Review
- Tributyltin and Zebrafish: Swimming in Dangerous Water.Frontiers in endocrinology · 2018Review
- Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis.PLoS genetics · 2017Article
- Acute and developmental behavioral effects of flame retardants and related chemicals in zebrafish.Neurotoxicology and teratologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Environmental factors affecting nutrient availability during development can cause predisposition to diseases later in life. To identify chemicals in the environment capable of altering nutrient mobilization, we analyzed yolk malabsorption in the zebrafish embryo, which relies on maternally-derived yolk for nutrition during its first week of life. Embryos of the transgenic zebrafish line HGn50D, which fluoresce in the yolk syncytial layer, were exposed from two to five days post fertilization to different chemicals. We developed a software package to automatically and accurately segment and quantify the area of the fluorescing yolk in images captured at the end of the treatment period. Based on this quantification, we found that prochloraz decreased yolk absorption, while butralin, tetrabromobisphenol A, tetrachlorobisphenol A and tributyltin increased yolk absorption. Given the number and variety of industrial chemicals in commerce today, development of automated image processing to perform high-speed quantitative analysis of biological effects is an important step for enabling high throughput screening to identify chemicals altering nutrient absorption.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.