Evidence map›Paper›PMID 25462689›Full record

ArticleNeuroImage2015

Optogenetic fMRI reveals distinct, frequency-dependent networks recruited by dorsal and intermediate hippocampus stimulations.

Andrew J Weitz, Zhongnan Fang, Hyun Joo Lee, Robert S Fisher, Wesley C Smith, ManKin Choy, Jia Liu, Peter Lin, Matthew Rosenberg, Jin Hyung Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022
    Pooled it
  2. Article
  3. Article
  4. Rhythms in Longitudinal Thalamic Recordings are Linked to Seizure Risk.medRxiv : the preprint server for health sciences · 2025
    Article
  5. Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  6. Charting the path in rodent functional neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. The hearing hippocampus.Progress in neurobiology · 2022
    Review
  17. Article
  18. The lateral entorhinal cortex is a hub for local and global dysfunction in early Alzheimer's disease states.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Andrew J WeitzDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
Zhongnan FangDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA.
Hyun Joo LeeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
Robert S FisherDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
Wesley C SmithDepartment of Neuroscience, University of California, Los Angeles, CA 90095, USA.
ManKin ChoyDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
Jia LiuDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; Department of Neuroscience, University of California, Los Angeles, CA 90095, USA; Department of Electrical Engineering, University of California, Los Angeles, CA 90095, USA.
Peter LinDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA.
Matthew RosenbergDepartment of Electrical Engineering, University of California, Los Angeles, CA 90095, USA; Department of Psychology, University of California, Los Angeles, CA 90095, USA.
Jin Hyung LeeDepartment of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA; Department of Electrical Engineering, Stanford University, Stanford, CA 94305, USA; Department of Neurosurgery, Stanford, CA 94305, USA. Electronic address: ljinhy@stanford.edu.

Funding

In Vivo Control and Functional Visualization of Stem Cell-Driven CNS RegenerationDP2OD007265 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, JIN HYUNG · 2010 to 2010
$2.4M
Deconstructing Arousal Regulation Circuits for Optimal DBS Therapy DesignR01NS087159 · NINDS · STANFORD UNIVERSITY · PI LEE, JIN HYUNG · 2014 to 2018
$1.9M
Visualization of Neuro-Molecular Targeting using Distribution-Free, High-Res fMRIR00EB008738 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, JIN HYUNG · 2010 to 2012
$745k
Visualization of Neuro-Molecular Targeting using Distribution-Free, High-Res fMRIK99EB008738 · NIBIB · STANFORD UNIVERSITY · PI LEE, JIN HYUNG · 2008 to 2009
$174k
NIBIB NIH HHS 4R00EB008738NIBIB NIH HHS K99 EB008738NIBIB NIH HHS R00 EB008738NIH HHS 1DP2OD007265NIH HHS DP2 OD007265NINDS NIH HHS R01 NS087159
6 · The paper itself

Abstract

Although the connectivity of hippocampal circuits has been extensively studied, the way in which these connections give rise to large-scale dynamic network activity remains unknown. Here, we used optogenetic fMRI to visualize the brain network dynamics evoked by different frequencies of stimulation of two distinct neuronal populations within dorsal and intermediate hippocampus. Stimulation of excitatory cells in intermediate hippocampus caused widespread cortical and subcortical recruitment at high frequencies, whereas stimulation in dorsal hippocampus led to activity primarily restricted to hippocampus across all frequencies tested. Sustained hippocampal responses evoked during high-frequency stimulation of either location predicted seizure-like afterdischarges in video-EEG experiments, while the widespread activation evoked by high-frequency stimulation of intermediate hippocampus predicted behavioral seizures. A negative BOLD signal observed in dentate gyrus during dorsal, but not intermediate, hippocampus stimulation is proposed to underlie the mechanism for these differences. Collectively, our results provide insight into the dynamic function of hippocampal networks and their role in seizures.

Indexed as

AlgorithmsAnimalsDentate GyrusElectroencephalographyHippocampusImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleNerve NetOptogeneticsOxygenRatsRats, Sprague-DawleySeizuresOxygenBrain mappingFunctional MRIHippocampusOptogeneticsSeizure

Identifiers

PMID25462689
PMCPMC4409430

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.