ArticleAddictive behaviors2015
Externalizing behavior and emotion dysregulation are indicators of transmissible risk for substance use disorder.
Article in Addictive behaviors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Emotion regulation in substance use disorders: a systematic review and meta-analysis.Addiction (Abingdon, England) · 2023Pooled it
- Interplay of cultural beliefs, psychological disposition, and social milieu during childhood on development of substance use disorder by early adulthood.Experimental and clinical psychopharmacology · 2025Article
- The misnomer of substance use "stigma": Beneficial disapproval should not be conflated with mistreatment of users.Addiction research & theory · 2024Article
- The Concept of Resistance to Substance Use and a Research Approach: The Resist! Project.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2023Article
- Prenatal cocaine exposure and substance use disorder in emerging adulthood at age 21.Drug and alcohol dependence · 2023Article
- Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): II. Externalizing superspectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2021Article
- Adolescent Behavioral Characteristics Mediate Familial Effects on Alcohol Use and Problems in College-Bound Students.Substance abuse : research and treatment · 2020Article
- Predictors of five-year relapse rates of youths with substance abuse who underwent a family-oriented therapy program.Annals of general psychiatry · 2020Article
- Global white matter microstructural abnormalities associated with addiction liability score in drug naïve youth.Brain imaging and behavior · 2018Article
- Longitudinal Modeling of the Association Between Transmissible Risk, Affect During Drug Use and Development of Substance Use Disorder.Journal of addiction medicineArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundPsychological items discriminating children of fathers diagnosed with an illicit drug-related substance use disorder and normal controls are indicators of a unidimensional construct termed transmissible liability index (TLI) (Vanyukov et al., 2009). TLI is a highly heritable (Vanyukov et al., 2009; Hicks, Iacono, McGue, 2012) and valid (Vanyukov et al., 2009; Hicks et al., 2009; Kirisci et al., 2013a) measure of childhood liability to substance use disorders (SUDs).
aimsThis longitudinal study determined whether TLI has incremental validity for predicting SUD beyond commonly measured psychological indicators of risk.
methodsTLI and measures of executive cognitive capacity, emotion dysregulation and externalizing disturbance were administered to boys at ages 10-12 and 16. SUD outcome determined at age 22 was assessed as (1) any SUD, (2) the number of drug-specific SUDs, and (3) SUD severity.
resultsTLI predicted SUD beyond the contribution of measures of emotion dysregulation, executive cognitive capacity and externalizing disturbance. The association of emotion dysregulation and externalizing behavior at ages 10-12 and 16 with SUD at age 22 was also reduced to non-significance after controlling for transmissible risk measured by TLI.
conclusionsTLI's incremental validity beyond these latter indicators of risk points to its utility for identifying vulnerable youths requiring intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.