Evidence map›Paper›PMID 25462629›Full record

ReviewCurrent opinion in biotechnology2015

Ion mobility-mass spectrometry strategies for untargeted systems, synthetic, and chemical biology.

Jody C May, Cody R Goodwin, John A McLean

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jody C MayDepartment of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN 37235, USA.
Cody R GoodwinDepartment of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN 37235, USA.
John A McLeanDepartment of Chemistry, Vanderbilt Institute of Chemical Biology, Vanderbilt Institute for Integrative Biosystems Research and Education, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: john.a.mclean@vanderbilt.edu.

Funding

Neurovascular Unit on a Chip: Regional Chemical Communication, Drug and Toxin ResponsesUH3TR000491 · NCATS · VANDERBILT UNIVERSITY · PI GHOSH, CHAITALI, JANIGRO, DAMIR · 2014 to 2016
$3.8M
Neurovascular Unit on a Chip: Chemical Communication, Drug and Toxin ResponsesUH2TR000491 · NCATS · VANDERBILT UNIVERSITY · PI JANIGRO, DAMIR, NISWENDER, KEVIN D · 2012 to 2013
$2.2M
NCATS NIH HHS UH2 TR000491NCATS NIH HHS UH2TR000491NCATS NIH HHS UH3 TR000491
6 · The paper itself

Abstract

Contemporary strategies that concentrate on only one or a handful of molecular targets limits the utility of the information gained for diagnostic and predictive purposes. Recent advances in the sensitivity, speed, and precision of measurements obtained from ion mobility coupled to mass spectrometry (IM-MS) have accelerated the utility of IM-MS in untargeted, discovery-driven studies in biology. Perhaps most evident is the impact that such wide-scale discovery capabilities have yielded in the areas of systems, synthetic, and chemical biology, where the need for comprehensive, hypothesis-driving studies from multidimensional and unbiased data is required.

Indexed as

Biochemical PhenomenaHumansIonsMass SpectrometryIons

Identifiers

PMID25462629
PMCPMC4297680

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.