ArticleGenomics, proteomics & bioinformatics2014
Computational prediction of microRNAs from Toxoplasma gondii potentially regulating the hosts' gene expression.
Article in Genomics, proteomics & bioinformatics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Is Toxoplasma Gondii Infection a Risk Factor for Leukemia? An Evidence-Based Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2016Pooled it
- MicroRNAs: master regulators in host-parasitic protist interactions.Open biology · 2022Review
- Circulating microRNA-122 in HCV cirrhotic patients with high frequency of genotype 3.PloS one · 2022Article
- Noncoding RNAs in Apicomplexan Parasites: An Update.Trends in parasitology · 2020Review
- SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- Seroprevalence and risk factors ofPeerJ · 2019Article
- On the performance of pre-microRNA detection algorithms.Nature communications · 2017Article
- Circulating microRNAs in malaria infection: bench to bedside.Malaria journal · 2017Review
- The Expressed MicroRNA-mRNA Interactions ofFrontiers in microbiology · 2017Article
- Identification and characterization of microRNAs in the zoonotic fluke Fasciolopsis buski.Parasitology research · 2016Article
- Tying malaria and microRNAs: from the biology to future diagnostic perspectives.Malaria journal · 2016Review
- Feature Selection Has a Large Impact on One-Class Classification Accuracy for MicroRNAs in Plants.Advances in bioinformatics · 2016Article
- The impact of feature selection on one and two-class classification performance for plant microRNAs.PeerJ · 2016Article
- One Step Forward, Two Steps Back; Xeno-MicroRNAs Reported in Breast Milk Are Artifacts.PloS one · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs (miRNAs) were discovered two decades ago, yet there is still a great need for further studies elucidating their genesis and targeting in different phyla. Since experimental discovery and validation of miRNAs is difficult, computational predictions are indispensable and today most computational approaches employ machine learning. Toxoplasma gondii, a parasite residing within the cells of its hosts like human, uses miRNAs for its post-transcriptional gene regulation. It may also regulate its hosts' gene expression, which has been shown in brain cancer. Since previous studies have shown that overexpressed miRNAs within the host are causal for disease onset, we hypothesized that T. gondii could export miRNAs into its host cell. We computationally predicted all hairpins from the genome of T. gondii and used mouse and human models to filter possible candidates. These were then further compared to known miRNAs in human and rodents and their expression was examined for T. gondii grown in mouse and human hosts, respectively. We found that among the millions of potential hairpins in T. gondii, only a few thousand pass filtering using a human or mouse model and that even fewer of those are expressed. Since they are expressed and differentially expressed in rodents and human, we suggest that there is a chance that T. gondii may export miRNAs into its hosts for direct regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.