ArticleRedox biology2014
Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress.
Article in Redox biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 136 citations in OpenAlex.
- Tissue-specific oxidative responses and recovery following acute thermal stress in juvenile Amazonian fish Colossoma macropomum.Fish physiology and biochemistry · 2026Article
- The association between heat waves and pregnancy outcome among women undergoing assisted reproductive technology in Sichuan, China.BMC public health · 2026Article
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- Biological shifts of endemic pearl mullet (Alburnus tarichi) during spawning migration between a highly alkaline soda lake and a river.Fish physiology and biochemistry · 2026Article
- Spirulina-coenzyme Q10 nanoemulsion regulating growth, antioxidant, immune capacity, histopathological alterations in Nile tilapia exposed to heat stress.Scientific reports · 2026Article
- Chronic Heat Stress Induces Stage-Specific Molecular and Physiological Responses in Spotted Seabass (Biology · 2026Article
- Genome-wide characterization and seasonal modulation of Hsp60 expression in juvenile Hilsa Shad across distinct upstream habitats.Journal, genetic engineering & biotechnology · 2025Article
- Changes in flexibility but not in compactness underlie the thermal adaptation of prokaryotic adenylate kinases.Evolution letters · 2025Article
- Heat Tolerance inAntioxidants (Basel, Switzerland) · 2025Article
- Investigating the mechanism of heat-shock protection in ISKNV-infected tilapia brain cell line.Microbiology spectrum · 2025Article
- Chromosome-level genome assembly of the doctor fish (Garra rufa).Scientific data · 2025Article
- State of thermal tolerance in an endangered himalayan fish Tor putitora revealed by expression modulation in environmental stress related genes.Scientific reports · 2025Article
- Heat acclimation mediates cellular protection via HSP70 stabilization of HIF-1α protein in extreme environments.International journal of biological sciences · 2025Article
- Toward sustainable crops: integrating vegetative (non-seed) lipid storage, carbon-nitrogen dynamics, and redox regulation.Frontiers in plant science · 2025Review
- Genetics and ontogeny are key factors influencing thermal resilience in a culturally and economically important bivalve.Scientific reports · 2024Article
- Genetic characterization, structural analysis, and detection of positive selection in small heat shock proteins of Cypriniformes and Clupeiformes.Fish physiology and biochemistry · 2024Article
- Effect of temperature on growth, survival, and chronic stress responses of Arctic Grayling juveniles.Transactions of the American Fisheries Society · 2024Article
- Article
- Evaluation and validation of reference genes for RT-qPCR gene expression in Naegleria gruberi.Scientific reports · 2023Article
- A Review on the Involvement of Heat Shock Proteins (Extrinsic Chaperones) in Response to Stress Conditions in Aquatic Organisms.Antioxidants (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat shock proteins (HSPs), originally identified as heat-inducible gene products, are a family of highly conserved proteins that respond to a wide variety of stress including oxidative stress. Although both acute and chronic oxidative stress have been well demonstrated to induce HSP responses, little evidence is available whether increased HSP levels provide enhanced protection against oxidative stress under elevated yet sublethal temperatures. We studied relationships between oxidative stress and HSPs in a physiological model by using Garra rufa (doctor fish), a fish species naturally acclimatized to different thermal conditions. We compared fish naturally living in a hot spring with relatively high water temperature (34.4±0.6°C) to those living in normal river water temperature (25.4±4.7°C), and found that levels of all the studied HSPs (HSP70, HSP60, HSP90, HSC70 and GRP75) were higher in fish living in elevated water temperature compared with normal river water temperature. In contrast, indicators of oxidative stress, including protein carbonyls and lipid hydroperoxides, were decreased in fish living in the elevated temperature, indicating that HSP levels are inversely associated with oxidative stress. The present results provide evidence that physiologically increased HSP levels provide protection against oxidative stress and enhance cytoprotection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.