Evidence map›Paper›PMID 25461952›Full record

ArticlePloS one2014

Decrease in vitamin D status in the Greenlandic adult population from 1987-2010.

Nina O Nielsen, Marit E Jørgensen, Henrik Friis, Mads Melbye, Bolette Soborg, Charlotte Jeppesen, Marika Lundqvist, Arieh Cohen, David M Hougaard, Peter Bjerregaard

Abstract read
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  8. Article
  9. Evolutionary Perspective in Rickets and Vitamin D.Frontiers in endocrinology · 2019
    Review
  10. Article
  11. Article
  12. Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nina O NielsenNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
Marit E JørgensenSteno Diabetes Centre, Gentofte, Denmark.
Henrik FriisDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Mads MelbyeDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Bolette SoborgDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Charlotte JeppesenDepartment of Public Health, Aarhus University, Aarhus, Denmark.
Marika LundqvistDepartment of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark.
Arieh CohenDepartment of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark.
David M HougaardDepartment of Clinical Biochemistry and Immunology, Statens Serum Institut, Copenhagen, Denmark.
Peter BjerregaardNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark; Greenland Centre for Health Research, University of Greenland, Nuuk, Greenland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow vitamin D status may be pronounced in Arctic populations due to limited sun exposure and decreasing intake of traditional food.

objectiveTo investigate serum 25(OH)D3 as a measure of vitamin D status among adult Inuit in Greenland, predictors of low serum 25(OH)D3 concentrations and the trend from 1987 to 2005-2010.

designA total of 2877 randomly selected Inuit (≥ 18 years) from the Inuit Health in Transition study were included. A sub-sample (n = 330) donated a blood sample in 1987 which allowed assessment of time trends in vitamin D status.

resultsThe geometric mean serum 25(OH)D3 (25[OH]D2 concentrations were negligible and not reported) in 2005-2010 was lowest among the 18-29 year old individuals (30.7 nmol/L; 95% CI: 29.7; 31.7) and increased with age. In all age-groups it decreased from 1987 to 2005-2010 (32%-58%). Low 25(OH)D3 concentrations (<50 nmol/L) were present in 77% of the 18-29 year old and decreased with age. A characteristic seasonal variation in 25(OH)D3 concentrations was observed (range 33.2-57.1 nmol/L, p<0.001), with the highest concentrations in August to October. Age (2.0% per year increase; CI: 1.7, 2.2), female gender (7.1%; CI: 2.0; 12.5), alcohol intake (0.2% per increase in drinks/week; 0.0; 0.4), and traditional diet (10.0% per 100 g/d increase; CI: 7.9; 12.1) were associated with increased serum 25(OH)D3, whereas smoking (-11.6%; CI: -16.2; -6.9), BMI (-0.6%; CI: -1.1; -0.2) and latitude (-0.7% per degree increase; CI: -1.3; -0.2) were associated with decreased concentrations.

conclusionWe identified a remarkable decrease in vitamin D status from 1987 to 2005-2010 and a presently low vitamin D status among Inuit in Greenland. A change away from a traditional diet may well explain the observed decline. The study argues for the need of increased dietary intake of vitamin D and supplementation might be considered.

Indexed as

Dietary SupplementsAdolescentAdultAgedAlcohol DrinkingArctic RegionsDietFeeding BehaviorFemaleGreenlandHumansMaleMiddle AgedVitamin DVitamin D DeficiencyVitamin D

Identifiers

PMID25461952
PMCPMC4252033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.