ArticlePloS one2014
Several genes encoding enzymes with the same activity are necessary for aerobic fungal degradation of cellulose in nature.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 53 citations in OpenAlex.
- Fungal-bacterial interaction networks in lignocellulose degradation: an integrated ecological and mechanistic perspective.Biotechnology for biofuels and bioproducts · 2026Review
- From Isolation to Genomics: Characterization ofJournal of fungi (Basel, Switzerland) · 2025Article
- Genomic and Multi-Omics Analysis ofJournal of fungi (Basel, Switzerland) · 2025Article
- Comparative genomic insight into the myxobacterial carbohydrate-degrading potential.Frontiers in microbiology · 2025Article
- Engineering the secretome of Aspergillus niger for cellooligosaccharides production from plant biomass.Microbial cell factories · 2024Article
- Genome Characteristics of the Endophytic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Hybrid Assembly Improves Genome Quality and Completeness ofJournal of fungi (Basel, Switzerland) · 2022Article
- Neotropical termite microbiomes as sources of novel plant cell wall degrading enzymes.Scientific reports · 2020Article
- Comparative Genomics Uncovers the Genetic Diversity and Synthetic Biology of Secondary Metabolite Production ofMycobiology · 2020Article
- Proteomic enzyme analysis of the marine fungus Paradendryphiella salina reveals alginate lyase as a minimal adaptation strategy for brown algae degradation.Scientific reports · 2019Article
- Carbohydrate Hydrolytic Potential and Redundancy of an Anaerobic Digestion Microbiome Exposed to Acidosis, as Uncovered by Metagenomics.Applied and environmental microbiology · 2019Article
- Article
- Characterization of novel lignocellulose-degrading enzymes from the porcupine microbiome using synthetic metagenomics.PloS one · 2019Article
- Enzyme Activities at Different Stages of Plant Biomass Decomposition in Three Species of Fungus-Growing Termites.Applied and environmental microbiology · 2018Article
- Structure, computational and biochemical analysis of PcCel45A endoglucanase from Phanerochaete chrysosporium and catalytic mechanisms of GH45 subfamily C members.Scientific reports · 2018Article
- Genome mining for peptidases in heat-tolerant and mesophilic fungi and putative adaptations for thermostability.BMC genomics · 2018Article
- Homology to peptide pattern for annotation of carbohydrate-active enzymes and prediction of function.BMC bioinformatics · 2017Article
- Key Ecological Roles for Zoosporic True Fungi in Aquatic Habitats.Microbiology spectrum · 2017Review
- Efficient screening of potential cellulases and hemicellulases produced by Bosea sp. FBZP-16 using the combination of enzyme assays and genome analysis.World journal of microbiology & biotechnology · 2017Article
- Aspergillus hancockii sp. nov., a biosynthetically talented fungus endemic to southeastern Australian soils.PloS one · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cellulose-degrading fungal enzymes are glycoside hydrolases of the GH families and lytic polysaccharide monooxygenases. The entanglement of glycoside hydrolase families and functions makes it difficult to predict the enzymatic activity of glycoside hydrolases based on their sequence. In the present study we further developed the method Peptide Pattern Recognition to an automatic approach not only to find all genes encoding glycoside hydrolases and lytic polysaccharide monooxygenases in fungal genomes but also to predict the function of the genes. The functional annotation is an important feature as it provides a direct route to predict function from primary sequence. Furthermore, we used Peptide Pattern Recognition to compare the cellulose-degrading enzyme activities encoded by 39 fungal genomes. The results indicated that cellobiohydrolases and AA9 lytic polysaccharide monooxygenases are hallmarks of cellulose-degrading fungi except brown rot fungi. Furthermore, a high number of AA9, endocellulase and β-glucosidase genes were identified, not in what are known to be the strongest, specialized lignocellulose degraders but in saprophytic fungi that can use a wide variety of substrates whereas only few of these genes were found in fungi that have a limited number of natural, lignocellulotic substrates. This correlation suggests that enzymes with different properties are necessary for degradation of cellulose in different complex substrates. Interestingly, clustering of the fungi based on their predicted enzymes indicated that Ascomycota and Basidiomycota use the same enzymatic activities to degrade plant cell walls.
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